Fig. 12
From: Developing hydrogels for gene therapy and tissue engineering
Applications of therapeutic gene hydrogels in hair regeneration. A miR-218-5p-containing exosomes modulate the β-catenin signaling pathway to promote hair regrowth. (i) Schematic representation of dermal papilla globules promoting hair by secreting exosomes; (ii) Exosome hydrogel promotes back hair regeneration in mice. (Reproduced with permission from Ref. [246], Copyright 2020, American Association for the Advancement of Science). B LPN microneedle patch delivers miR-218 to promote hair regrowth. (i) Schematic representation of the preparation of MN/LPNs/miR-218; (ii) Schematic representation of hair regeneration in mice administered at different times. (Reproduced with permission from Ref. [156], Copyright 2022, Royal Society of Chemistry)