Fig. 7
From: Developing hydrogels for gene therapy and tissue engineering
Applications of therapeutic gene hydrogels in bone regeneration. A Effect of Exos hydrogel on osteogenesis of bone marrow mesenchymal stem cells. (i) Exosomal miR-708-5p inhibits osteogenic differentiation of BMSCs; (ii) Exos hydrogel to treat infected bone nonunion. (Reproduced with permission from Ref. [117], Copyright 2022, American Chemical Society). B Accelerated bone repair in rats with uMSC-derived Exos. (i) Schematic diagram of uMSC-derived Exos accelerating bone repair in rats; (ii) Masson’s trichrome staining; (iii) promoting neovascularization; (iv) realizing bone repair. (Reproduced with permission from Ref. [183], Copyright 2021, American Chemical Society)