Fig. 9
From: Developing hydrogels for gene therapy and tissue engineering
Applications of therapeutic gene hydrogels in eye diseases. A HA hydrogel loaded with miRNA 24-3p exosome promotes corneal epithelial healing. (i) Exos-miRNA 24-3p hydrogel for repair after corneal epithelial defects; (ii) Evaluation of in vitro release of Exos-miRNA in a rabbit corneal epithelial defect model. (Reproduced with permission from Ref. [16], Copyright 2022, Elsevier). B Temperature-sensitive hydrogel regenerates corneal epithelium after piggybacking on Exos. (i) Extracellular matrix (ECM) remodeling after anterior corneal plate injury; (ii) Repair of the anterior corneal lamina propria by the CHI hydrogel. (Reproduced with permission from Ref. [218], Copyright 2022, Elsevier)