Fig. 6

Biodistribution of HMNVs in ApoE^−/− mouse. A Schematic of biodistribution of HMNVs. HMNVs (labeled and unlabeled with DiO/DiR) were injected into ApoE^−/− mice with or without MF, then analyzed by live imaging and immunofluorescence for tracking at 12 h or 72 h post-injection. B Representative in vivo imaging system (IVIS) images of mice and aorta injected with HMNVs via tail vein. C Representative confocal laser scanning microscopy (CLSM) images of the HMNVs in the aorta root (green). The nuclei were counter-stained with Hoechst (blue). Scale bar = 500 or 100 μm. D Quantitative analysis of the fluorescence intensity. Data are presented as mean ± SEM (n = 3 per group). Statistical significance was determined by one-way ANOVA with Tukey’s post hoc test. **P < 0.01. ns, no significance