Fig. 7
HMNVsM−D together with MF attenuate atherosclerotic lesions in ApoE−/− mice. A. Schematic of the experimental procedure. PBS, HMNVsM, HMNVsM−D were injected into ApoE−/− mice via the tail vein weekly. B Representative images of Oil Red O staining of the atherogenic lesion area in mice. C Percentage of the aortic lesion area. D Representative aortic arch view of the atherosclerotic lesions in ApoE−/− mice treated as indicated. E–G Representative images of the atherogenic lesion area stained with hematoxylin and eosin (H&E), Masson’s trichrome, and Oil Red O. Scale bar = 200 μm. H–K Quantitative analysis of the aortic lesion, necrotic core area, plaque collagen area relative to plaque area, lesion areas relative to plaque area. All data are expressed as mean ± SD (n = 6 per group). Statistical significance was determined by one-way ANOVA with Tukey’s post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001. ns, no significance