Fig. 8

Evaluation of the safety of Hm@TSA/As-MOF. Tissue slices of internal organs were used to observe the effects of drugs in mice (A). The heart, spleen, lung and kidney indices of mice were evaluated and statistically analysed (n = 5) (B). AST, ALT, BUN and CREA levels were evaluated to assess the liver and kidney function of mice (n = 3) (C). The RBC count, WBC count, HGB level and PLT count of mice were evaluated and statistically analysed (n = 5) (D). The haemolytic properties of TSA&As and Hm@TSA/As-MOF were tested and statistically analysed (n = 3) (E). The body weight of mice in each group was monitored and recorded during treatment (n = 8) (F). Data are expressed as the mean ± SD (***, p < 0.001; two-tailed Student’s t-test)