Scheme 1.From: Mesoporous silica coated spicules for photodynamic therapy of metastatic melanomaThe topical application of mSHS with PpIX incorporated (mSHS@PpIX) for photodynamic therapy of metastatic melanoma. mSHS @ PpIX penetrate the skin, releasing PpIX into the skin and tumor tissue. Subsequently, PpIX generates singlet oxygen when triggered by laser irradiation (at 635Â nm), which then kills tumor cellsBack to article page