Table 1 Examples of drugs/agents capable of affecting some of the MDR genes in human cancer cells
From: NANOMEDICINE: will it offer possibilities to overcome multiple drug resistance in cancer?
Signal chain | Blocking agents | Clinical status | Ref. |
|---|---|---|---|
Wnt | siRNA Curcumin/Piperin Several other natural products Resveratrol | 35 clinical trials | |
NOTCH | siRNA Monoclonal antibodies Peptides Decoys Secretase inhibitors Several natural compounds | 15 clinical trials | [56] [225] [226] [53] [227] |
Hgh | Cyclopamine (alkaloid from plants) Vismodelib Cyclosporin Sulforaphane (Broccoli) | Several clinical trials Clinical trials | [229] [58] [230] |
NANOG | siRNA Resveratrol | Preclinical | [231] [232] |