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Table 2 Transmission-reducing activity of Pfs25 spy-VLP vaccine induced IgG

From: Bacterial superglue enables easy development of efficient virus-like particle based vaccines

  Control serum Serum from Pfs25 spy-VLP immunized mice
Tested concentrations (µg/ml) of purified total serum IgG 750 750 250 83.3 27.8
Detected oocysts per 20 tested mosquitoes 133 0 1 5 97
Median (25 and 75 percentiles) 5.5 (3:10) 0 (0:0) 0 (0:0) 0 (0:0) 4.0 (2:6.75)
Transmission-reducing activity (%)a 100 99.2 96.2 27.1
P valueb <0.001 <0.001 <0.001 0.704
  1. aTotal oocyst count in mosquitoes fed with anti-Pfs25 IgG/total oocyst count in mosquitoes fed with control serum IgG × 100
  2. bMann–Whitney Rank Sum Test