Bacterial superglue enables easy development of efficient virus-like particle based vaccines

Table 2 Transmission-reducing activity of Pfs25 spy-VLP vaccine induced IgG

	Control serum	Serum from Pfs25 spy-VLP immunized mice
Tested concentrations (µg/ml) of purified total serum IgG	750	750	250	83.3	27.8
Detected oocysts per 20 tested mosquitoes	133	0	1	5	97
Median (25 and 75 percentiles)	5.5 (3:10)	0 (0:0)	0 (0:0)	0 (0:0)	4.0 (2:6.75)
Transmission-reducing activity (%)^a	–	100	99.2	96.2	27.1
P value^b	–	<0.001	<0.001	<0.001	0.704

^aTotal oocyst count in mosquitoes fed with anti-Pfs25 IgG/total oocyst count in mosquitoes fed with control serum IgG × 100
^bMann–Whitney Rank Sum Test

ISSN: 1477-3155