Fig. 2
From: Nanotechnology advances towards development of targeted-treatment for obesity
Copyright 2014, Nature journals
Reversal of obesity using PHB-targeted pro-apoptotic agent. The WAT is highly vascularized, during development of obesity it expresses pro-angiogenic markers that can serve as a target for treatment of obesity (a). Targeting the WAT vasculature of obese mice with AHP-KLA reduced vascularization associated with obesity (b). This was accompanied by reductions in body weights (c) and WAT mass (d). Reproduced with permission [11].