Fig. 6
From: Nanotechnology advances towards development of targeted-treatment for obesity
Copyright 2017, American Chemical Society
Transformation of subcutaneous WAT into BAT using transcutaneous microneedle Rosi-NP patches. Rosi-NP were prepared by encapsulating Rosi, glucose oxidase (GOx) and catalase (CAT) in pH responsive dextran NPs coated with alginate. The glucose-responsive dextran NPs (Rosi NP) reduced animal bodyweight through browning of WAT by encapsulated Rosi, these effects were comparable to a potent thermogenic activator (CL, CL 316,243). The difference was statistical significant compared to rats subjected to empty vehicle patches (EV). Reproduced with permission [16].