Advances in aptamer screening and aptasensors’ detection of heavy metal ions

Guo, Wenfei; Zhang, Chuanxiang; Ma, Tingting; Liu, Xueying; Chen, Zhu; Li, Song; Deng, Yan

doi:10.1186/s12951-021-00914-4

Journal of Nanobiotechnology

Table 2 A summary of developments of optical aptasensor for heavy material ions

From: Advances in aptamer screening and aptasensors’ detection of heavy metal ions

Target	Type	LOD (nM)	LinearRange (nM)	Aptamer	Refs
Pb²⁺	FRET	4.1	0–50	AAGGG TGGGT GGGT	[85]
Pb²⁺	SERS	0.07	0.13–53.33	GGTTG GTGTG GTGGT TGGTG TTGG	[86]
Pb²⁺	Colorimetric	3.04	4.83–1447.88	GGGTG GGTGG GTGGG T	[87]
Pb²⁺	Colorimetric	100	500–10,000	GTGGG TAGGG CGGGT TGG	[89]
Pb²⁺	QCM	4	5–200	TTTTT TACCC AGGGT GGGTG GGTGG GT	[91]
Pb²⁺	Fluorescence	60.7	100–1000	GACGA CGGCC AGTAG CTGAC ATCAG TGTAC GATCT AGTCG TC	[52]
Hg⁺	Colorimetric	0.049	0.82–62	TTTTT TTTTT	[96]
Hg⁺	Colorimetric	10.5	50–6000	TTTTT TTTTT TTTTT TTTTT TTT	[97]
Hg⁺	SPR	0.026	0.05–100	TTTTT ATTCT TTCTT CCCCC CGGTT GTTTG TTT	[99]
Hg⁺	Fluorescence	0.2	2–160	TTCTT TCTTC TTTC	[100]
Hg⁺	FRET	4.92	500–7000	AATAG CTTTG CTCTC TCGTT T	[101]
Cd²⁺	Colorimetric	9.96	17.79–177.92	ACCGA CCGTG CTGGA CTCTG GACTG TTGTG GTATT ATTTT TGGTT GTGCA GTATG AGCGA GCGTT GCG	[105]
Cd²⁺	Fluorescence	2.15	7.19–5000	GGGGA CTGTT GTGGT ATTAT TTTTG GTTGT GCAGT	[107]
Cd²⁺	Colorimetric	5 × 10^–3	0.02–2 × 10⁵	ACCGACCGTGCTGGACTCTGGACTGTTGTGGTA TTATTTTTGGTTGTGCAGTATGAGCGAGCGTTGCG	[108]
As³⁺	Colorimetric	185	/	GGTAA TACGA CTCAC TATAG GGAGA TACCA GCTTA TTCAA TTTAA GAACA ACCAA CGTCG CTCCG GGTAC TTCTT CATCA GATAG TAAGC AATCT	[110]
As³⁺	Colorimetric	217	12.8–1282.9	GGTAA TACGC TCACT ATAGG GAGAT ACCAG CTTAT TCAAT TTTAC AGAAC AACCA ACGTC GCTCC GGGTA CTTCT TCATC GAGAT AGTAA GTGCA ATCT	[111]
As³⁺	Fluorescence	2 × 10^–3	0.001–1000	GGTAA TACGA CTCAC TATAG GGAGA TACCA GCTTA TTCAA TTTTA CAGAA CAACC AACGT CGCTC CGGGT ACTTC TTCAT CGAGA TAGTA AGTGC AATCT	[112]
As³⁺	Colorimetric	0.128	0.32–9.62	ATGCA AACCC TTAAG AAAGT GGTCG TCCAA AAAAC CATTG	[113]
Ag⁺	Colorimetric	4.1 × 10^–5	5.7 × 10^–5–0.57	CCCCC CCGTG GGTAG GGCGG GTTGG ACCCT ACCCA CCCCC CCG	[114]
Ag⁺; Hg²⁺	Fluorescence	1.01 × 10^–3; 1.33 × 10^–3	0.05–50; 0.05–50	CCCCC CCCCC CC; TTTTT TTTTT TT	[116]
Hg²⁺; Pb²⁺; Ag⁺	Fluorescence	0.2; 0.5; 2	0.3–14; 0.8–38; 4.2–210	TTCTT TCTTA ACTTG TTTGT TCAC; GGAAG GTGTG GAAGG AAC; CTCTC TTCTC TTCAT AAATC AACAC AACAC ACAAA	[117]
Pb²⁺; Hg²⁺	ECL	0.024; 0.0041	0.1–10⁴; 0.01–100	AAAAA AAAAG GGG TTTTT TAAAA TTTTT T	[119]

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