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Table 2 A summary of developments of optical aptasensor for heavy material ions

From: Advances in aptamer screening and aptasensors’ detection of heavy metal ions

Target Type LOD (nM) LinearRange (nM) Aptamer Refs
Pb2+ FRET 4.1 0–50 AAGGG TGGGT GGGT [85]
Pb2+ SERS 0.07 0.13–53.33 GGTTG GTGTG GTGGT TGGTG TTGG [86]
Pb2+ Colorimetric 3.04 4.83–1447.88 GGGTG GGTGG GTGGG T [87]
Pb2+ Colorimetric 100 500–10,000 GTGGG TAGGG CGGGT TGG [89]
Pb2+ QCM 4 5–200 TTTTT TACCC AGGGT GGGTG GGTGG GT [91]
Pb2+ Fluorescence 60.7 100–1000 GACGA CGGCC AGTAG CTGAC ATCAG TGTAC GATCT AGTCG TC [52]
Hg+ Colorimetric 0.049 0.82–62 TTTTT TTTTT [96]
Hg+ Colorimetric 10.5 50–6000 TTTTT TTTTT TTTTT TTTTT TTT [97]
Hg+ SPR 0.026 0.05–100 TTTTT ATTCT TTCTT CCCCC CGGTT GTTTG TTT [99]
Hg+ Fluorescence 0.2 2–160 TTCTT TCTTC TTTC [100]
Hg+ FRET 4.92 500–7000 AATAG CTTTG CTCTC TCGTT T [101]
Cd2+ Colorimetric 9.96 17.79–177.92 ACCGA CCGTG CTGGA CTCTG GACTG TTGTG GTATT ATTTT TGGTT GTGCA GTATG AGCGA GCGTT GCG [105]
Cd2+ Fluorescence 2.15 7.19–5000 GGGGA CTGTT GTGGT ATTAT TTTTG GTTGT GCAGT [107]
Cd2+ Colorimetric 5 × 10–3 0.02–2 × 105 ACCGACCGTGCTGGACTCTGGACTGTTGTGGTA TTATTTTTGGTTGTGCAGTATGAGCGAGCGTTGCG [108]
As3+ Colorimetric 185 / GGTAA TACGA CTCAC TATAG GGAGA TACCA GCTTA TTCAA TTTAA GAACA ACCAA CGTCG CTCCG GGTAC TTCTT CATCA GATAG TAAGC AATCT [110]
As3+ Colorimetric 217 12.8–1282.9 GGTAA TACGC TCACT ATAGG GAGAT ACCAG CTTAT TCAAT TTTAC AGAAC AACCA ACGTC GCTCC GGGTA CTTCT TCATC GAGAT AGTAA GTGCA ATCT [111]
As3+ Fluorescence 2 × 10–3 0.001–1000 GGTAA TACGA CTCAC TATAG GGAGA TACCA GCTTA TTCAA TTTTA CAGAA CAACC AACGT CGCTC CGGGT ACTTC TTCAT CGAGA TAGTA AGTGC AATCT [112]
As3+ Colorimetric 0.128 0.32–9.62 ATGCA AACCC TTAAG AAAGT GGTCG TCCAA AAAAC CATTG [113]
Ag+ Colorimetric 4.1 × 10–5 5.7 × 10–5–0.57 CCCCC CCGTG GGTAG GGCGG GTTGG ACCCT ACCCA CCCCC CCG [114]
Ag+; Hg2+ Fluorescence 1.01 × 10–3; 1.33 × 10–3 0.05–50;
0.05–50
CCCCC CCCCC CC;
TTTTT TTTTT TT
[116]
Hg2+; Pb2+; Ag+ Fluorescence 0.2; 0.5; 2 0.3–14; 0.8–38; 4.2–210 TTCTT TCTTA ACTTG TTTGT TCAC;
GGAAG GTGTG GAAGG AAC;
CTCTC TTCTC TTCAT AAATC AACAC AACAC ACAAA
[117]
Pb2+; Hg2+ ECL 0.024; 0.0041 0.1–104; 0.01–100 AAAAA AAAAG GGG
TTTTT TAAAA TTTTT T
[119]