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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Engineering stem cells to produce exosomes with enhanced bone regeneration effects: an alternative strategy for gene therapy

Fig. 3

MSC-BMP2-Exo exhibited excellent cellular uptake efficiency and biocompatibility. a Fluorescent microscopic image showed the cellular internalization of MSC-BMP2-Exo and MSC-Exo by recipient cells after overnight incubation. Exosomes were stained by Dio with green fluorescent, Scale bar: 20 μm. b Flow cytometry analysis of Dio-labeled exosomes engulfed by recipient cells. c Ratios of recipient cells that had engulfed MSC-BMP2-Exo or MSC-Exo. Cells cultured in normal medium without exosomes were also detected as control group, n = 3. d Cell viability of hMSCs incubated with exosomes and Lipo/pBMP2 complex was determined by CCK-8 assay, n = 6. *p < 0.05, **p < 0.01, ***p < 0.001

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Journal of Nanobiotechnology

ISSN: 1477-3155

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