Varderidou-Minasian S, Lorenowicz MJ. Mesenchymal stromal/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities. Theranostics. 2020;10:5979–97.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jiang S, Tian G, Yang Z, Gao X, Wang F, Li J, Tian Z, Huang B, Wei F, Sang X, Shao L, Zhou J, Wang Z, Liu S, Sui X, Guo Q, Guo W, Li X. Enhancement of acellular cartilage matrix scaffold by Wharton’s jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration. Bioact Mater. 2021;6:2711–28.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xu X, Liang Y, Li X, Ouyang K, Wang M, Cao T, Li W, Liu J, Xiong J, Li B, Xia J, Wang D, Duan L. Exosome-mediated delivery of kartogenin for chondrogenesis of synovial fluid-derived mesenchymal stem cells and cartilage regeneration. Biomaterials. 2021;269:120539.
Article
CAS
PubMed
Google Scholar
Duan MN, Zhang Y, Zhang HY, Meng YP, Qian M, Zhang GK. Epidermal stem cell-derived exosomes promote skin regeneration by downregulating transforming growth factor-beta 1 in wound healing. Stem Cell Res Ther. 2020;11:452.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liu A, Lin D, Zhao H, Chen L, Cai B, Lin K, Shen SGF. Optimized BMSC-derived osteoinductive exosomes immobilized in hierarchical scaffold via lyophilization for bone repair through Bmpr2/Acvr2b competitive receptor-activated Smad pathway. Biomaterials. 2021;272:120718.
Article
CAS
PubMed
Google Scholar
Hu SQ, Li ZH, Shen DL, Zhu DS, Huang K, Su T, Dinh PU, Cores J, Cheng K. Exosome-eluting stents for vascular healing after ischaemic injury. Nat Biomed Eng. 2021;5:1174–88.
Article
CAS
PubMed
Google Scholar
Mendt M, Rezvani K, Shpall E. Mesenchymal stem cell-derived exosomes for clinical use. Bone Marrow Transplant. 2019;54:789–92.
Article
PubMed
Google Scholar
Zhai MM, Zhu Y, Yang MY, Mao CB. Human Mesenchymal stem cell derived exosomes enhance cell-free bone regeneration by altering their miRNAs profiles. Adv Sci. 2020;7:2001334.
Article
CAS
Google Scholar
Brennan MA, Layrolle P, Mooney DJ. Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration. Adv Funct Mater. 2020;30:1909125.
Article
CAS
PubMed
PubMed Central
Google Scholar
Malda J, Boere J, van de Lest CHA, van Weeren PR, Wauben AHM. Extracellular vesicles—new tool for joint repair and regeneration. Nat Rev Rheumatology. 2016;12:243–9.
Article
CAS
PubMed
Google Scholar
Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367:640.
Article
Google Scholar
Zhou B, Xu K, Zheng X, Chen T, Wang J, Song Y, Shao Y, Zheng S. Application of exosomes as liquid biopsy in clinical diagnosis. Signal Transduct Target Ther. 2020;5:144.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lei Q, Gao F, Liu T, Ren WX, Chen L, Cao YL, Chen WL, Guo SJ, Zhang Q, Chen WQ, Wang HX, Chen ZC, Li QB, Hu Y, Guo AY. Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow-derived mesenchymal stem cells and slow age-related degeneration. Sci Transl Med. 2021;13:eaaz8697.
Article
CAS
PubMed
Google Scholar
Bjorge IM, Kim SY, Mano JF, Kalionis B, Chrzanowski W. Extracellular vesicles, exosomes and shedding vesicles in regenerative medicine—a new paradigm for tissue repair. Biomater Sci. 2017;6:60–78.
Article
CAS
PubMed
Google Scholar
Mittelbrunn M, Sanchez-Madrid F. Intercellular communication: diverse structures for exchange of genetic information. Nat Rev Mol Cell Biol. 2012;13:328–35.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mercier V, Larios J, Molinard G, Goujon A, Matile S, Gruenberg J, Roux A. Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation. Nat Cell Biol. 2020;22:947–59.
Article
CAS
PubMed
PubMed Central
Google Scholar
McNally EK, Brett CL. The intralumenal fragment pathway mediates ESCRT-independent surface transporter down-regulation. Nat Commun. 2018;9:5358.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhao LW, Gu CY, Gan Y, Shao LL, Chen HW, Zhu HY. Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis. J Control Release. 2020;318:1–15.
Article
CAS
PubMed
Google Scholar
Yim N, Ryu SW, Choi K, Lee KR, Lee S, Choi H, Kim J, Shaker MR, Sun W, Park JH, Kim D, Heo WD, Choi C. Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein-protein interaction module. Nat Commun. 2016;7:12277.
Article
CAS
PubMed
PubMed Central
Google Scholar
Richter M, Vader P, Fuhrmann G. Approaches to surface engineering of extracellular vesicles. Adv Drug Deliv Rev. 2021;173:416–26.
Article
CAS
PubMed
Google Scholar
Du W, Zhang KY, Zhang SQ, Wang R, Nie Y, Tao HY, Han ZB, Liang L, Wang D, Liu JF, Liu N, Han ZC, Kong DL, Zhao Q, Li ZJ. Enhanced proangiogenic potential of mesenchymal stem cell-derived exosomes stimulated by a nitric oxide releasing polymer. Biomaterials. 2017;133:70–81.
Article
CAS
PubMed
Google Scholar
Huang CC, Kang MY, Lu Y, Shirazi S, Diaz JI, Cooper LF, Gajendrareddy P, Ravindran S. Functionally engineered extracellular vesicles improve bone regeneration. Acta Biomater. 2020;109:182–94.
Article
CAS
PubMed
PubMed Central
Google Scholar
Venkatesan JK, Rey-Rico A, Meng W, Cai X, Pons F, Lebeau L, Migonney V, Madry H, Cucchiarini M. Biomaterial-assisted gene therapy for translational approaches to treat musculoskeletal disorders. Mater Today Adv. 2021;9:100126.
Article
CAS
Google Scholar
Yang Z, Shi J, Xie J, Wang Y, Sun J, Liu T, Zhao Y, Zhao X, Wang X, Ma Y, Malkoc V, Chiang C, Deng W, Chen Y, Fu Y, Kwak KJ, Fan Y, Kang C, Yin C, Rhee J, Bertani P, Otero J, Lu W, Yun K, Lee AS, Jiang W, Teng L, Kim BYS, Lee LJ. Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation. Nat Biomed Eng. 2020;4:69–83.
Article
CAS
PubMed
Google Scholar
Jeppesen DK, Fenix AM, Franklin JL, Higginbotham JN, Zhang Q, Zimmerman LJ, Liebler DC, Ping J, Liu Q, Evans R, Fissell WH, Patton JG, Rome LH, Burnette DT, Coffey RJ. Reassessment of exosome composition. Cell. 2019;177:428–45.
Article
CAS
PubMed
PubMed Central
Google Scholar
Witwer KW, Wolfram J. Extracellular vesicles versus synthetic nanoparticles for drug delivery. Nat Rev Mater. 2021;6:103–6.
Article
CAS
Google Scholar
Cheng L, Sharples RA, Scicluna BJ, Hill AF. Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood. J Extracell Vesicles. 2014;3:23743.
Article
Google Scholar
Ullah M, Kodam SP, Mu Q, Akbar A. Microbubbles versus extracellular vesicles as therapeutic cargo for targeting drug delivery. ACS Nano. 2021;15:3612–20.
Article
CAS
PubMed
Google Scholar
Luan X, Sansanaphongpricha K, Myers I, Chen H, Yuan H, Sun D. Engineering exosomes as refined biological nanoplatforms for drug delivery. Acta Pharmacol Sin. 2017;38:754–63.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liao W, Du Y, Zhang CH, Pan FW, Yao Y, Zhang T, Peng Q. Exosomes: the next generation of endogenous nanomaterials for advanced drug delivery and therapy. Acta Biomater. 2019;86:1–14.
Article
CAS
PubMed
Google Scholar
Zhu XH, Badawi M, Pomeroy S, Sutaria DS, Xie ZL, Baek A, Jiang JM, Elgamal OA, Mo XK, La Perle K, Chalmers J, Schmittgen TD, Phelps MA. Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells. J Extracell Vesicles. 2017;6:1324730.
Article
PubMed
PubMed Central
Google Scholar
Sun L, Fan M, Huang D, Li B, Xu R, Gao F, Chen Y. Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis. Biomaterials. 2021;271:120761.
Article
CAS
PubMed
Google Scholar
Han Z, Liu SQ, Pei YG, Ding Z, Li YG, Wang XG, Zhan DQ, Xia SL, Driedonks T, Witwer KW, Weiss RG, van Zijl PCM, Bulte JWM, Cheng LZ, Liu GS. Highly efficient magnetic labelling allows MRI tracking of the homing of stem cell-derived extracellular vesicles following systemic delivery. J Extracell Vesicles. 2021;10:e12054.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhan Q, Yi K, Li X, Cui X, Yang E, Chen N, Yuan X, Zhao J, Hou X, Kang C. Phosphatidylcholine-engineered exosomes for enhanced tumor cell uptake and intracellular antitumor drug delivery. Macromol Biosci. 2021;21:2100042.
Article
CAS
Google Scholar
Garcia-Arranz M, Herreros MD, Gonzalez-Gomez C, de la Quintana P, Guadalajara H, Georgiev-Hristov T, Trebol J, Garcia-Olmo D. Treatment of Crohn’s-related rectovaginal fistula with allogeneic expanded-adipose derived stem cells: a phase I-IIa clinical trial. Stem Cells Transl Med. 2016;5:1441–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Trounson A, DeWitt ND. Pluripotent stem cells progressing to the clinic. Nat Rev Mol Cell Biol. 2016;17:194–200.
Article
CAS
PubMed
Google Scholar
Heslop JA, Hammond TG, Santeramo I, Piella AT, Hopp I, Zhou J, Baty R, Graziano EI, Marco BP, Caron A, Skold P, Andrews PW, Baxter MA, Hay DC, Hamdam J, Sharpe ME, Patel S, Jones DR, Reinhardt J, Danen EHJ, Ben-David U, Stacey G, Bjorquist P, Piner J, Mills J, Rowe C, Pellegrini G, Sethu S, Antoine DJ, Cross MJ, Murray P, Williams DP, Kitteringham NR, Goldring CEP, Park BK. Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies. Stem Cell Transl Med. 2015;4:389–400.
Article
CAS
Google Scholar
van Niel G, D’Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19:213–28.
Article
PubMed
Google Scholar
Xing HY, Zhang ZJ, Mao QJ, Wang CG, Zhou YL, Zhou XP, Ying LW, Xu HB, Hu SJ, Zhang N. Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration. J Nanobiotechnol. 2021;19:1–15.
Article
Google Scholar
Xu LZ, Faruqu FN, Lim YM, Lim KY, Liam-Or R, Walters AA, Lavender P, Fear D, Wells CM, Wang JTW, Al-Jamal KT. Exosome-mediated RNAi of PAK4 prolongs survival of pancreatic cancer mouse model after loco-regional treatment. Biomaterials. 2021;264:120369.
Article
CAS
PubMed
Google Scholar
Li SP, Lin ZX, Jiang XY, Yu XY. Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools. Acta Pharm Sin. 2018;39:542–51.
Article
CAS
Google Scholar
Kay MA. State-of-the-art gene-based therapies: the road ahead. Nat Rev Genet. 2011;12:316–28.
Article
CAS
PubMed
Google Scholar
Tsuji K, Bandyopadhyay A, Harfe BD, Cox K, Kakar S, Gerstenfeld L, Einhorn T, Tabin CJ, Rosen V. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nature Genet. 2006;38:1424–9.
Article
CAS
PubMed
Google Scholar
Ambrosi TH, Marecic O, McArdle A, Sinha R, Gulati GS, Tong X, Wang Y, Steininger HM, Hoover MY, Koepke LS, Murphy MP, Sokol J, Seo EY, Tevlin R, Lopez M, Brewer RE, Mascharak S, Lu L, Ajanaku O, Conley SD, Seita J, Morri M, Neff NF, Sahoo D, Yang F, Weissman IL, Longaker MT, Chan CKF. Aged skeletal stem cells generate an inflammatory degenerative niche. Nature. 2021;597:256–62.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bez M, Pelled G, Gazit D. BMP gene delivery for skeletal tissue regeneration. Bone. 2020;137:115449.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hsieh MK, Wu CJ, Chen CC, Tsai TT, Niu CC, Wu SC, Lai PL. BMP-2 gene transfection of bone marrow stromal cells to induce osteoblastic differentiation in a rat calvarial defect model. Mater Sci Eng C-Mater Biol Appl. 2018;91:806–16.
Article
CAS
PubMed
Google Scholar
Szostak N, Royo F, Rybarczyk A, Szachniuk M, Blazewicz J, del Sol A, Falcon-Perez JM. Sorting signal targeting mRNA into hepatic extracellular vesicles. RNA Biol. 2014;11:836–44.
Article
PubMed
PubMed Central
Google Scholar
Kamal AF, Siahaan OSH, Fiolin J. Various dosages of BMP-2 for management of massive bone defect in Sprague Dawley rat. Arch Bone Jt Surg. 2019;7:498–505.
PubMed
PubMed Central
Google Scholar
Yin B, Ma Q, Song C, Zhao L, Yu F, Wang C, Shi Y, Ye L. Exosome-derived noncoding RNAs as a promising treatment of bone regeneration. Stem Cells Int. 2021;2021:1–8.
Article
Google Scholar
Oliveira AC, Ferraz MP, Monteiro FJ, Simoes S. Cationic liposome-DNA complexes as gene delivery vectors: development and behaviour towards bone-like cells. Acta Biomater. 2009;5:2142–51.
Article
CAS
PubMed
Google Scholar
Valente JFA, Pereira P, Sousa A, Queiroz JA, Sousa F. Effect of plasmid DNA size on chitosan or polyethyleneimine polyplexes formulation. Polymers. 2021;13:793.
Article
CAS
PubMed
PubMed Central
Google Scholar
Baghaei M, Tekie FSM, Khoshayand MR, Varshochian R, Hajiramezanali M, Kachousangi MJ, Dinarvand R, Atyabi F. Optimization of chitosan-based polyelectrolyte nanoparticles for gene delivery, using design of experiment: in vitro and in vivo study. Mater Sci Eng C-Mater Biol Appl. 2021;118:111036.
Article
CAS
PubMed
Google Scholar
Torralba D, Baixauli F, Villarroya-Beltri C, Fernandez-Delgado I, Latorre-Pellicer A, Acin-Perez R, Martin-Cofreces NB, Jaso-Tamame AL, Iborra S, Jorge I, Gonzalez-Aseguinolaza G, Garaude J, Vicente-Manzanares M, Enriquez JA, Mittelbrunn M, Sanchez-Madrid F. Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts. Nat Commun. 2018;9:2658.
Article
PubMed
PubMed Central
Google Scholar
Koltover I, Salditt T, Radler JO, Safinya CR. An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery. Science. 1998;281:78–81.
Article
CAS
PubMed
Google Scholar
Rehman ZU, Hoekstra D, Zuhorn IS. Mechanism of polyplex- and lipoplex-mediated delivery of nucleic acids: real-time visualization of transient membrane destabilization without endosomal lysis. ACS Nano. 2013;7:3767–77.
Article
Google Scholar
Morille M, Passirani C, Vonarbourg A, Clavreul A, Benoit JP. Progress in developing cationic vectors for non-viral systemic gene therapy against cancer. Biomaterials. 2008;29:3477–96.
Article
CAS
PubMed
Google Scholar
Villarroya-Beltri C, Baixauli F, Mittelbrunn M, Fernandez-Delgado I, Torralba D, Moreno-Gonzalo O, Baldanta S, Enrich C, Guerra S, Sanchez-Madrid F. ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins. Nat Commun. 2016;7:13588.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kwon SH, Al Faruque H, Kee H, Kim E, Park S. Exosome-based hybrid nanostructures for enhanced tumor targeting and hyperthermia therapy. Colloid Surf B-Biointerfaces. 2021;205:111915.
Article
CAS
Google Scholar
Yang BW, Chen Y, Shi JL. Exosome biochemistry and advanced nanotechnology for next-generation theranostic platforms. Adv Mater. 2019;31:1802896.
Article
Google Scholar
Sharma S, Masud MK, Kaneti YV, Rewatkar P, Koradia A, Hossain MSA, Yamauchi Y, Popat A, Salomon C. Extracellular vesicle nanoarchitectonics for novel drug delivery applications. Small. 2021;17:2102220.
Article
CAS
Google Scholar
Yang M, Liu Q, Huang TL, Tan WJ, Qu LB, Chen TK, Pan HB, Chen L, Liu JS, Wong CW, Lu WW, Guan M. Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development. Theranostics. 2020;10:10874.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yue JH, Wu J, Liu D, Zhao XL, Lu WW. BMP2 gene delivery to bone mesenchymal stem cell by chitosan-g-PEI nonviral vector. Nanoscale Res Lett. 2015;10:203.
Article
PubMed
PubMed Central
Google Scholar
Dash M, Palaniyandi K, Ramalingam S, Sahabudeen S, Raja NS. Exosomes isolated from two different cell lines using three different isolation techniques show variation in physical and molecular characteristics. Biochim Biophys Acta Biomembr. 2020;1863:183490.
Article
PubMed
Google Scholar
Zha Y, Li Y, Lin T, Chen J, Zhang S, Wang J. Progenitor cell-derived exosomes endowed with VEGF plasmids enhance osteogenic induction and vascular remodeling in large segmental bone defects. Theranostics. 2021;11:397–409.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gupta D, Zickler AM, El Andaloussi S. Dosing extracellular vesicles. Adv Drug Deliv Rev. 2021;178:113961.
Article
CAS
PubMed
Google Scholar