Antibacterial metal nanoclusters

Zheng, Youkun; Wei, Min; Wu, Haibin; Li, Fangyuan; Ling, Daishun

doi:10.1186/s12951-022-01538-y

Journal of Nanobiotechnology

Table 1 Antibacterial applications of metal NCs

From: Antibacterial metal nanoclusters

Formulations	Target pathogens	Antibacterial mechanisms	References
Au₂₅(MHA)₁₈	Gram-negative bacteria; Gram-positive bacteria	Membrane damage; ROS generation; metabolic imbalance	[24]
GSH-Ag⁺-R NCs	Gram-negative bacteria; Gram-positive bacteria	Membrane damage; Ag⁺ release; ROS generation	[22]
AuDAMP	Gram-negative bacteria; Gram-positive bacteria	Membrane damage; ROS generation; DNA damage	[38]
Antimicrobial peptide-AuNCs	Gram-negative bacteria; Gram-positive bacteria	Membrane damage; delivery of antimicrobial peptide	[41]
QA-AuNCs	MRSA	Membrane damage; ROS generation; metabolic disturbance	[42]
MUTAB-AuNCs	Gram-negative bacteria; Gram-positive bacteria	Membrane damage; ROS generation	[43]
AuMS	Gram-negative bacteria; Gram-positive bacteria	Membrane damage	[44]
MSA-AgNCs	Gram-negative bacteria; Gram-positive bacteria	Ag⁺ release	[51]
TA-CuNCs	Gram-positive bacteria	Membrane damage; Cu⁺ release	[52]
Cys-AuNCs	E. coli	ROS generation	[57]
N-heterocyclic carbene-AuNCs	Gram-negative bacteria; Gram-positive bacteria; fungi	Membrane damage; ROS generation	[58]
AuPt bimetallic NCs	Gram-negative bacteria	Membrane damage; metabolic disturbance	[62]
Ag₃NCs	E. coli	ROS generation; DNA damage	[63]
Histidine-AuNCs	Gram-negative bacteria	ROS generation; metabolic disturbance	[64]
Imidazole-AuNCs	S. aureus	ROS generation; metabolic disturbance	[65]
TPPMS/Ac₄GlcSH-AuNCs	Gram-negative bacteria; Gram-positive bacteria	ROS generation; metabolic disturbance; DNA damage	[66]
Lys-AuNCs-Amp	MRSA and its persister	Delivery of ampicillin	[69]
Vancomycin-loaded Pep-AuNCs	S. aureus	Delivery of vancomycin	[70]
DNase-AuNCs	E. coli; S. aureus	PTT; PDT	[73]
Au₂₅(Cys)₁₈/crystal violet	E. coli; S. aureus	PDT	[75]
Chitosan-AgNCs	E. coli	PTT	[76]
Au_xAg_25−x(MHA)₁₈ alloy NCs	S. aureus	ROS generation	[35]
DNA-stabilized AgNCs	Gram-negative bacteria; Gram-positive bacteria	ROS generation	[86]
rAgNAs	MRSA	Membrane damage; Ag⁺ release	[91]
Dap-AuNCs	MRSA	Membrane damage; ROS generation; DNA damage	[95]
Dap-AgNCs	Gram-positive bacteria	Membrane damage; ROS generation; DNA damage	[96]
SFT/DT-AuNCs	Gram-negative bacteria; Gram-positive bacteria	Membrane damage	[97]
Dpep-AgNCs	Gram-negative bacteria	Cell wall damage; Ag⁺ release; delivery of antimicrobial peptide	[98]
AuNCs/Ho-GO nanosheets	Gram-negative bacteria; Gram-positive bacteria	Membrane damage; ROS generation; metabolic disturbance	[101]
Au₂₅(MBA)₁₈/MXene	S. aureus	Membrane damage; ROS generation; metabolic disturbance; DNA damage	[102]
Au NCs/CS	Gram-negative bacteria; Gram-positive bacteria	Membrane damage	[105]
Prot/MTU-AuNCs	E. coli; S. aureus	ROS generation	[108]
MSNs-AgNCs	Gram-negative bacteria; Gram-positive bacteria	Membrane damage; Ag⁺ release; ROS generation	[110]
pMBA-AuNCs	ESBL E. coli; MRSA	Membrane damage; intracellular component destruction	[111]
ABA-AuNCs	Gram-negative bacteria	Cell wall damage	[113]
QA-AuNCs/indocyanine green	MRSA	Membrane damage; PTT; PDT	[114]

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ISSN: 1477-3155

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