Skip to main content

Retraction Note to: A stepwise-targeting strategy for the treatment of cerebral ischemic stroke

The Original Article was published on 17 November 2021

Retraction to: Journal of Nanobiotechnology (2021) 19:371

The Editors-in-Chief have retracted this article. After publication, the following concerns were raised:

  • in Fig. 3, the Heart/Saline panel and Heart/Micelle panels partially overlap, respectively, with the Heart/HA-CUR panel and Heart/CUR panel in Fig. S2 in [1];

  • in Fig. 3, the Heart/Saline and Heart/Micelles panels partially overlap, respectively, with Heart/DEX-SS-IND and Heart/Saline panel in Fig. 7 in [2];

  • in Fig. 4a, the TGN/cy3 micelles panel in 2.0 h line overlaps with the SA-DEX-CUR panel in the e-Selectin line in Fig. 4 in [3];

  • in Fig. 5D, panels H2O2 and H2O2 + TPP-MLT overlap, respectively, with panels PTX and FA@PPMoV@PTX in Fig. 4B in [4].

Following these concerns author Jingbo Hu contacted the journal requesting a retraction. They did not respond to the editor's request to share original data. The Editors-in-Chief therefore no longer have confidence in the integrity of the data in this article.

Jingbo Hu agrees to this retraction. The other authors have not responded to any correspondence from the editor/publisher about this retraction.


  1. Hu J, Li Sh, Kang X, Qi J, Wu J, Wang X, Xu X, Ying X, Jiang S, You J, Du Y. CD44-targeted hyaluronic acid-curcumin prodrug protects renal tubular epithelial cell survival from oxidative stress damage. Carbohyd Polym. 2018;193:268–80.

    Article  CAS  Google Scholar 

  2. Wang S, Tan X, Li S, Zhou Y, Geng P, Hua A, Deng A, Yu Z. Indomethacin-based stimuli-responsive micelles combined with paclitaxel to overcome multidrug resistance. Oncotarget. 2017;8(67):111281.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Hu JB, Liu D, Qi J, Lu KJ, Jin FY, Ying XY, You J, Du YZ. An E-selectin targeting and MMP-2-responsive dextran–curcumin polymeric prodrug for targeted therapy of acute kidney injury. Biomater Sci. 2018;6(12):3397–409.

    Article  PubMed  CAS  Google Scholar 

  4. Peng J, Yin Y, Liang H, Lu Y, Zheng H, Wu G, Rao S, Chen J, Yan F, Hu J. Tumor microenvironment responsive pepper mild mottle virus-based nanotubes for targeted delivery and controlled release of paclitaxel. Front Bioeng Biotechnol. 2021;9: 763661.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Jingbo Hu, Jiejun Peng or Jin Liu.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hu, J., Tan, X., Wang, D. et al. Retraction Note to: A stepwise-targeting strategy for the treatment of cerebral ischemic stroke. J Nanobiotechnol 20, 443 (2022).

Download citation

  • Published:

  • DOI: