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Table 1 Antitumor marketed products containing Mylabris or its related active ingredients

From: Review targeted drug delivery systems for norcantharidin in cancer therapy

Marketed product

Drug dosage form

Composition

Indications

Specification

Usage

Sodium Demethylcantharidate for Injection

Injection

Sodium Demethylcantharidate

For liver cancer, esophagus cancer, gastric and cardia cancer, lung cancer, and so on, and leukopenia. It can also be used as a preoperative drug for cancer or used in combined chemotherapy

10 mg/20 mg/30 mg (calculated as norcantharidin)

Intravenous injection; hepatic artery cannulation; intratumoral injection

Sodium Demethylcantharidate Injection

Injection

Sodium Demethylcantharidate

For liver cancer, esophagus cancer, gastric and cardia cancer, lung cancer, and so on, and leukopenia. It can also be used as a preoperative drug for cancer or used in combined chemotherapy

2 mL: 10 mg (calculated as norcantharidin)

Intravenous injection; hepatic artery cannulation; intratumoral injection

Sodium Demethylcantharidate and Sodium Chloride Injection

Injection

Sodium Demethylcantharidate, Sodium Chloride

For liver cancer, esophagus cancer, gastric and cardia cancer, lung cancer, and so on, and leukopenia. It can also be used as a preoperative drug for cancer or used in combined chemotherapy

250 mL: 30 mg (calculated as norcantharidin) and sodium chloride 2.25 g

Intravenous slow drip

Disodium Cantharidinate Injection

Injection

Disodium Cantharidinate

For primary liver cancer and other tumors and leukopenia. It can also be used for hepatitis, liver cirrhosis and hepatitis B virus carriers.

10 mL: 0.5 mg/2 mL: 0.1 mg/5 mL: 0.25 mg

Intravenous drip

Disdium Cantharidinate and Vitamin B6 Injection

Injection

Disodium Cantharidinate and Vitamin B6

For liver cancer, lung cancer and leukopenia. It can also be used for hepatitis, cirrhosis and hepatitis B virus carriers

5 mL: 0.05 mg/10 mL: 0.1 mg

Intravenous drip

Cantharidatis Sodium Tablets

Tablet

Disodium Cantharidinate

Antitumor drugs. For primary liver cancer and other tumors and leukopenia. It can also be used for hepatitis, liver cirrhosis and hepatitis B virus carriers.

0.5 mg

Oral

Methylcantharidinmide Tablets

Tablet

Methylcantharidinmide

For primary liver cancer

25 mg/10 mg

Oral

Compound Cantharidin Capsule

Capsule

Mylabris, Panax ginseng,

Astragali Radix, Acanthopanax senticosus, Sparganii Rhizoma, Scutellaria barbata, Curcuma zedoaria, Corni Fructus, Ligustri Lucidi Fructus,

bear bile powder, licorice

Removing blood and stasis, attacking poison and eroding sores. For primary liver cancer, lung cancer, rectal cancer, malignant lymphoma, gynecological malignant tumor, and so on.

0.25 g/capsule

Oral

Demethylcantharidin Tablets

Tablet

Norcantharidin

For liver cancer, esophageal cancer, gastric and cardia cancer, and so on, and leukopenia, hepatitis, cirrhosis, hepatitis B virus carriers.

5 mg

Oral

Aidi Injection

Injection

Mylabris, Panax ginseng, Astragali Radix, Acanthopanax senticosus

Clearing away heat and detoxifying, dissipating blood stasis and dissipating stagnation. For primary liver cancer, lung cancer, rectal cancer, malignant lymphoma, gynecological malignant tumor, and so on.

10 mL each

Intravenous drip

Delisheng Injection

Injection

Red ginseng, Astragali Radix, Bufonis Venenum, Mylabris

Nourish Qi and strengthen the body, relieve swelling and loose knot. For middle and advanced primary liver cancer with Qi deficiency and blood stasis syndrome, symptoms include mass in the right flank, persistent pain, abdominal distension, lack of appetite, and fatigue.

10 mL each

Intravenous drip

Ganning Tablets

Tablet

Mylabris, Arnebiae Radix, Glutinous rice

Clearing away heat and detoxifying, removing dampness, removing blood stasis and dissipating stagnation. It is used for the treatment of various acute and chronic hepatitis, especially for those with abnormal liver function and positive surface antigen in hepatitis B patients, and it can prevent hepatitis B from developing cancer.

Each tablet weighs 0.3 g

Oral

Hupo Zhitong plaster

Rubber plaster

Kaempferiae Rhizoma, Acorus Tatarinowii, Coptidis Rhizoma, Strychni Semen, Mylabris, Clematis chinensis Osbeck, Arisaematis Rhizoma, Bufonis Venenum, Amber oil, Basil oil, Peppermint oil, Star anise oil, Chinese cinnamon oil, Borneol, Camphor

Promote blood circulation and resolve phlegm, reduce swelling and dissipate knots, and relieve pain by dredging collaterals. For tumor pain, neuropathic pain, rheumatic arthralgia, bruises and blood stasis caused by phlegm and blood stasis

6 cm × 10 cm/piece

For external use, stick to the washed affected area