Engineered extracellular vesicles for ischemic stroke: a systematic review and meta-analysis of preclinical studies

Table 4 Extended risk of bias checklist data

Study	Peer reviewed	Temperature control	Random allocation	Allocation concealment	Blinded assessment	Appropriate animal models	Suitable for anesthetics	Sample size calculation	Animal welfare regulations	Conflict of interest	Total Score
Deng et al., 2019	√	√	√	√		√	√		√	√	8
Guo_1 et al., 2020	√		√	√		√			√	√	6
Guo_2 et al., 2021	√	√	√			√			√	√	6
Huang et al., 2020	√	√				√	√		√	√	6
Jiang et al., 2022	√	√	√			√	√		√	√	7
Kim_1 et al., 2019	√					√	√		√		4
Kim_2 et al., 2020	√	√				√	√		√	√	6
Kim_3 et al., 2021	√	√			√	√	√		√		6
Lee et al., 2016	√	√	√	√	√	√	√		√	√	9
Li et al., 2020	√	√	√			√	√		√		6
Liu et al., 2022	√					√			√	√	4
Pan et al., 2020	√	√				√	√		√	√	6
Shi et al., 2022	√	√			√	√	√		√	√	7
Wang et al., 2020	√	√	√	√	√	√	√		√	√	9
Wei et al., 2022	√	√	√	√		√	√		√	√	8
Xin_1 et al., 2017	√	√			√	√	√		√	√	7
Xin_2 et al., 2021	√	√			√	√	√		√	√	7
Xu_1 et al., 2020	√	√	√	√	√	√	√		√	√	9
Xu_2 et al., 2022	√	√	√	√	√	√	√		√	√	9
Yang_1 et al., 2020	√	√	√	√	√	√	√	√	√	√	10
Yang_2 et al., 2020	√	√	√	√	√	√	√		√	√	9
Yang_3 et al., 2022	√	√				√	√		√	√	6
Yoon et al., 2022	√	√				√	√		√	√	6
Zhang et al., 2020	√	√	√	√	√	√	√		√	√	9
Zhao et al., 2020	√	√	√	√	√	√	√		√	√	9
Zhou_1 et al., 2022	√	√	√			√	√		√	√	7
Zhou_2 et al., 2023	√	√	√			√	√		√	√	7
Zhu et al., 2022	√	√	√			√	√		√	√	7

ISSN: 1477-3155