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  1. It is extremely difficult to develop targeted treatments for triple-negative breast (TNB) cancer, because these cells do not express any of the key biomarkers usually exploited for this goal.

    Authors: Shiwei Niu, Gareth R. Williams, Jianrong Wu, Junzi Wu, Xuejing Zhang, Xia Chen, Shude Li, Jianlin Jiao and Li-Min Zhu
    Citation: Journal of Nanobiotechnology 2019 17:95
  2. The persistence, biodistribution, and risk of integration into the host genome of any new therapeutic DNA vaccine must be established in preclinical studies. We previously developed the DNA vaccine pcDNA-CCOL2A1 ...

    Authors: Xiao Zhao, Juan Long, Fei Liang, Nan Liu, Yuying Sun and Yongzhi Xi
    Citation: Journal of Nanobiotechnology 2019 17:94
  3. Exosomes (Exo) hold great promise as endogenous nanocarriers that can deliver biological information between cells. However, Exo are limited in terms of their abilities to target specific recipient cell types....

    Authors: Chunai Gong, Jing Tian, Zhuo Wang, Yuan Gao, Xin Wu, Xueying Ding, Lei Qiang, Guorui Li, Zhimin Han, Yongfang Yuan and Shen Gao
    Citation: Journal of Nanobiotechnology 2019 17:93
  4. The selectively accumulate in tumor site and completely release drug within cancer cells great limit the therapeutic effect of nano-drug delivery system. Moreover, absence of appropriate biomarker is one of th...

    Authors: Yifan Wang, Yanqiu Zhang, Zhengxing Ru, Wei Song, Lin Chen, Hao Ma and Lizhu Sun
    Citation: Journal of Nanobiotechnology 2019 17:91
  5. Radiopharmaceuticals have proven to be effective agents, since they can be successfully applied for both diagnostics and therapy. Effective application of relevant radionuclides in pre-clinical and clinical st...

    Authors: Oleksii O. Peltek, Albert R. Muslimov, Mikhail V. Zyuzin and Alexander S. Timin
    Citation: Journal of Nanobiotechnology 2019 17:90

    The Correction to this article has been published in Journal of Nanobiotechnology 2020 18:2

  6. The emergence of resistance to chemotherapy or target therapy, tumor metastasis, and systemic toxicity caused by available anticancer drugs hamper the successful colorectal cancer (CRC) treatment. The rise in ...

    Authors: Shu-Ting Hong, Huaching Lin, Chen-Shen Wang, Chih-Hsien Chang, Anya Maan-Yuh Lin, James Chih-Hsin Yang and Yu-Li Lo
    Citation: Journal of Nanobiotechnology 2019 17:89
  7. Gold nanoparticles (AuNPs) have been proposed for many applications in medicine and bioanalysis. For use in all these applications, maintaining the stability of AuNPs in solution by suppressing aggregation is ...

    Authors: Zhanwu Hou, Zhen Wang, Run Liu, Hua Li, Zhengyi Zhang, Tian Su, Jeffy Yang and Huadong Liu
    Citation: Journal of Nanobiotechnology 2019 17:88
  8. Adoptive T cell-transfer (ATC) therapy is a highly promising cancer-treatment approach. However, in vivo-administered T cells tend to disperse, with only a small proportion reaching the tumour. To remedy this,...

    Authors: Laura Sanz-Ortega, Yadileiny Portilla, Sonia Pérez-Yagüe and Domingo F. Barber
    Citation: Journal of Nanobiotechnology 2019 17:87
  9. Controllable and multiple DNA release is critical in modern gene-based therapies. Current approaches require complex assistant molecules for combined release. To overcome the restrictions on the materials and ...

    Authors: Xinyi Guo, Hongxiang Zhang, Yanyan Wang, Wei Pang and Xuexin Duan
    Citation: Journal of Nanobiotechnology 2019 17:86
  10. Lack of effective tumor-specific delivery systems remains an unmet clinical challenge for successful translation of innovative therapies, such as, therapeutic oligonucleotides. In the past decade, exosomes hav...

    Authors: Abi J. Vázquez-Ríos, Ángela Molina-Crespo, Belén L. Bouzo, Rafael López-López, Gema Moreno-Bueno and María de la Fuente
    Citation: Journal of Nanobiotechnology 2019 17:85
  11. Macrophages with tumor-tropic migratory properties can serve as a cellular carrier to enhance the efficacy of anti neoplastic agents. However, limited drug loading (DL) and insufficient drug release at the tum...

    Authors: Lei Qiang, Zheng Cai, Wenjun Jiang, Jiyong Liu, Zongguang Tai, Guorui Li, Chunai Gong, Shen Gao and Yuan Gao
    Citation: Journal of Nanobiotechnology 2019 17:83
  12. Skin damages are defined as one of most common lesions people suffer from, some of wounds are notoriously difficult to eradicate such as chronic wounds and deep burns. Existing wound therapies have been proved...

    Authors: Wei Wang, Kong-jun Lu, Chao-heng Yu, Qiao-ling Huang and Yong-Zhong Du
    Citation: Journal of Nanobiotechnology 2019 17:82
  13. Magnetic nanoparticles (MNPs) are characterized by unique physicochemical and biological properties that allow their employment as highly biocompatible drug carriers. Gelsolin (GSN) is a multifunctional actin-...

    Authors: Robert Bucki, Katarzyna Niemirowicz-Laskowska, Piotr Deptuła, Agnieszka Z. Wilczewska, Paweł Misiak, Bonita Durnaś, Krzysztof Fiedoruk, Ewelina Piktel, Joanna Mystkowska and Paul A. Janmey
    Citation: Journal of Nanobiotechnology 2019 17:81
  14. The gastric cancer is the second most malignant tumor in the world. HER-2 is one of the key targets for the gastric cancer therapy. Anti-HER-2 antibodies like trastuzumab, exhibits the satisfactory therapeutic...

    Authors: Jiayu Zhang, Tiancheng Zhao, Fanglei Han, Yu Hu and Yezhou Li
    Citation: Journal of Nanobiotechnology 2019 17:80
  15. Protein nanocages have emerged as popular nanocarriers for either drug delivery or biotemplates for the preparation of nanomaterials. However, only three interfaces, namely exterior surface, intersubunit and i...

    Authors: Jiachen Zang, Bowen Zheng, Xiuqing Zhang, Paolo Arosio and Guanghua Zhao
    Citation: Journal of Nanobiotechnology 2019 17:79
  16. The design of efficient drug delivery vectors requires versatile formulations able to simultaneously direct a multitude of molecular targets and to bypass the endosomal recycling pathway of cells. Liposomal-ba...

    Authors: Diego de la Fuente-Herreruela, Ajay K. Monnappa, Mónica Muñoz-Úbeda, Aarón Morallón-Piña, Eduardo Enciso, Luis Sánchez, Fabrice Giusti, Paolo Natale and Iván López-Montero
    Citation: Journal of Nanobiotechnology 2019 17:77
  17. Molybdenum disulfide (MoS2) has been widely explored for biomedical applications due to its brilliant photothermal conversion ability. In this paper, we report a novel multifunctional MoS2-based drug delivery sys...

    Authors: Chen Zhang, Doudou Zhang, Jian Liu, Jie Wang, Yusheng Lu, Junxia Zheng, Bifei Li and Lee Jia
    Citation: Journal of Nanobiotechnology 2019 17:76
  18. To improve the outcome of cancer treatment, the combination of multiple therapy models has proved to be effective and promising. Gas therapy (GT) and chemodynamic therapy (CDT), mainly targeting the mitochondr...

    Authors: Bin Zhao, Penghe Zhao, Zhaokui Jin, Mingjian Fan, Jin Meng and Qianjun He
    Citation: Journal of Nanobiotechnology 2019 17:75
  19. Diabetes is one of the biggest medical challenges worldwide. The key to efficiently treat type 1 diabetes is to accurately inject insulin according to the blood glucose levels. In this study, we aimed to devel...

    Authors: Yujie Zhang, Mingxin Wu, Wubin Dai, Min Chen, Zhaoyang Guo, Xin Wang, Di Tan, Kui Shi, Longjian Xue, Sheng Liu and Yifeng Lei
    Citation: Journal of Nanobiotechnology 2019 17:74
  20. Magnetic nanosensors have become attractive instruments for the diagnosis and treatment of different diseases. They represent an efficient carrier system in drug delivery or in transporting contrast agents. Fo...

    Authors: Simon Doswald, Wendelin Jan Stark and Beatrice Beck-Schimmer
    Citation: Journal of Nanobiotechnology 2019 17:73
  21. Nano-sized vesicles, so called extracellular vesicles (EVs), from regenerative cardiac cells represent a promising new therapeutic approach to treat cardiovascular diseases. However, it is not yet sufficiently...

    Authors: Christien M. Beez, Marion Haag, Oliver Klein, Sophie Van Linthout, Michael Sittinger and Martina Seifert
    Citation: Journal of Nanobiotechnology 2019 17:72
  22. The incidence of lung cancer continues to rise worldwide. Because the aggressive metastasis of lung cancer cells is the major drawback of successful therapies, the crucial challenge of modern nanomedicine is t...

    Authors: Monika Ruzycka, Mihaela R. Cimpan, Ivan Rios-Mondragon and Ireneusz P. Grudzinski
    Citation: Journal of Nanobiotechnology 2019 17:71
  23. Copper oxide nanomaterials (CuO NMs) are exploited in many products including inks, cosmetics, textiles, wood preservatives and food contact materials. Their incorporation into these products may enhance oral ...

    Authors: Victor C. Ude, David M. Brown, Vicki Stone and Helinor J. Johnston
    Citation: Journal of Nanobiotechnology 2019 17:70
  24. The major obstacle impeding human immunodeficiency virus-1 (HIV-1) eradication in antiretroviral treatment (ART) treated HIV-1 subjects is the establishment of long-lived latently infected resting CD4+ T cells. D...

    Authors: Ignacio Relaño-Rodríguez, Raquel Juárez-Sánchez, Carolina Pavicic, Eduardo Muñoz and Maria Ángeles Muñoz-Fernández
    Citation: Journal of Nanobiotechnology 2019 17:69
  25. Nanotechnology in medicine has greatly expanded the therapeutic strategy that may be explored for cancer treatment by exploiting the specific tumor microenvironment such as mild acidity, high glutathione (GSH)...

    Authors: Wei Tang, Hongbo Gao, Dalong Ni, QiFeng Wang, Bingxin Gu, Xinhong He and Weijun Peng
    Citation: Journal of Nanobiotechnology 2019 17:68
  26. Immunochromatographic strips (ICSs) are a practical tool commonly used in point-of-care testing (POCT) applications. However, ICSs that are currently available have low sensitivity and require expensive equipm...

    Authors: Qiangqiang Fu, Ze Wu, Jingxia Li, Zengfeng Wu, Hui Zhong, Quanli Yang, Qihui Liu, Zonghua Liu, Lianghe Sheng, Meng Xu, Tingting Li, Zhinan Yin and Yangzhe Wu
    Citation: Journal of Nanobiotechnology 2019 17:67
  27. The wide application of silver nanoparticles (AgNPs) in medicals and daily utensils increases the risk of human exposure. The study on cell and protein changes induced by medical AgNPs (20 nm) and Ag+ gave insigh...

    Authors: Wenxu Fang, Zhenxing Chi, Weiguo Li, Xunuo Zhang and Qiang Zhang
    Citation: Journal of Nanobiotechnology 2019 17:66
  28. It is essential that prophylactic drugs do not interfere with the normal function of the immune system. The use of nanoparticles as vaginal microbicides is a promising prevention strategy against sexually tran...

    Authors: Alba Martín-Moreno, Daniel Sepúlveda-Crespo, Mª Jesús Serramía-Lobera, Ana Judith Perisé-Barrios and Mª Angeles Muñoz-Fernández
    Citation: Journal of Nanobiotechnology 2019 17:65
  29. Age-related macular degeneration (AMD) is a leading cause of severe visual deficits and blindness. Meanwhile, there is convincing evidence implicating oxidative stress, inflammation, and neovascularization in ...

    Authors: Sisi Lai, Yanyan Wei, Quanwu Wu, Kang Zhou, Tuo Liu, Yingfeng Zhang, Ning Jiang, Wen Xiao, Junjie Chen, Qiuhong Liu and Yang Yu
    Citation: Journal of Nanobiotechnology 2019 17:64
  30. Silver ions from silver nanoparticles (AgNP) or AgNPs themselves itself that are ingested from consumer health care products or indirectly from absorbed food contact material can interact with the gastrointest...

    Authors: Sarah E. Orr, Kuppan Gokulan, Mary Boudreau, Carl E. Cerniglia and Sangeeta Khare
    Citation: Journal of Nanobiotechnology 2019 17:63
  31. Human hematopoietic progenitor cells (HPCs) are important for cell therapy in cancer and tissue regeneration. In vitro studies have shown a transient association of 40 nm polystyrene nanoparticles (PS NPs) wit...

    Authors: Bart Wathiong, Sarah Deville, An Jacobs, Nick Smisdom, Pascal Gervois, Ivo Lambrichts, Marcel Ameloot, Jef Hooyberghs and Inge Nelissen
    Citation: Journal of Nanobiotechnology 2019 17:62
  32. Protein shells assembled from viral coat proteins are an attractive platform for development of new vaccines and other tools such as targeted bioimaging and drug delivery agents. Virus-like particles (VLPs) de...

    Authors: Ilva Liekniņa, Gints Kalniņš, Ināra Akopjana, Jānis Bogans, Mihails Šišovs, Juris Jansons, Jānis Rūmnieks and Kaspars Tārs
    Citation: Journal of Nanobiotechnology 2019 17:61
  33. Nanoscale drug-delivery systems (DDSs) have great promise in tumor diagnosis and treatment. Platelet membrane (PLTM) biomimetic DDSs are expected to enhance retention in vivo and escape uptake by macrophages, ...

    Authors: Haijun Wang, Junzi Wu, Gareth R. Williams, Qing Fan, Shiwei Niu, Jianrong Wu, Xiaotian Xie and Li-Min Zhu
    Citation: Journal of Nanobiotechnology 2019 17:60
  34. Technology enabling the separation of rare circulating tumor cells (CTCs) provides the potential to enhance our knowledge of cancer metastasis and improve the care of cancer patients. Modern detection approach...

    Authors: Zhiming Li, Jun Ruan and Xuan Zhuang
    Citation: Journal of Nanobiotechnology 2019 17:59
  35. Iron oxide nanocomposites have received a great attention for their application in various fields like physics, medicine, biology, and material science etc., due to their unique properties, such as magnetism, ...

    Authors: Hind Baballa Gasmalla, Xiaoquan Lu, Mahgoub Ibrahim Shinger, Lubin Ni, Aadil Nabi Chishti and Guowang Diao
    Citation: Journal of Nanobiotechnology 2019 17:58
  36. Numerous first generation phosphorothioates (PS) and their derivatives have shown promise targeting mRNA for therapeutic applications and also gained market approval for their use as a drug. However, PS have n...

    Authors: Shipra Malik and Raman Bahal
    Citation: Journal of Nanobiotechnology 2019 17:57
  37. Titanium (Ti) and its alloys as bio-implants have excellent biocompatibilities and osteogenic properties after modification of chemical composition and topography via various methods. The corrosion resistance ...

    Authors: Wen-qing Zhu, Shui-yi Shao, Li-na Xu, Wan-qing Chen, Xiao-yu Yu, Kai-ming Tang, Ze-hua Tang, Fa-ming Zhang and Jing Qiu
    Citation: Journal of Nanobiotechnology 2019 17:55
  38. Nanomaterials that exhibit intrinsic enzyme-like characteristics have shown great promise as potential antibacterial agents. However, many of them exhibit inefficient antibacterial activity and biosafety probl...

    Authors: Chen Li, Yurong Sun, Xiaoping Li, Sanhong Fan, Yimin Liu, Xiumei Jiang, Mary D. Boudreau, Yue Pan, Xin Tian and Jun-Jie Yin
    Citation: Journal of Nanobiotechnology 2019 17:54
  39. Soil acidity (and associated Al toxicity) is a major factor limiting crop production worldwide and threatening global food security. Electrostatic layer-by-layer (LBL) self-assembly provides a convenient and v...

    Authors: Yingming Feng, Xuewen Li, Shaoxue Guo, Xingyun Chen, Tingxuan Chen, Yongming He, Sergey Shabala and Min Yu
    Citation: Journal of Nanobiotechnology 2019 17:53
  40. Currently, the main goal of cancer research is to increase longevity of patients suffering malignant cancers. The promising results of BCc1 in vitro and vivo experiments made us look into the effect of BCc1 na...

    Authors: Maryam Hafizi, Somayeh Kalanaky, Hassan moaiery, Maryam Khayamzadeh, Sajad Noorian, Vahid Kaveh, Behrooz Gharib, Hossein Foudazi, Mohsen Razavi, Arash Jenabian, Saeid Salimi, Mohammad Mahdi Adib Sereshki, Hamid Reza Mirzaei, Afshin Zarghi, Saideh Fakharzadeh, Mohammad Hassan Nazaran…
    Citation: Journal of Nanobiotechnology 2019 17:52
  41. Children born with a small or absent ear undergo surgical reconstruction to create a suitable replacement using rib cartilage. To overcome the donor site morbidity and long-term pain of harvesting rib cartilag...

    Authors: Michelle Griffin, Deepak Kalaskar and Peter Butler
    Citation: Journal of Nanobiotechnology 2019 17:51
  42. Improving the water solubility of hydrophobic photosensitizer and increasing its accumulation in tumor tissue are essential for in vivo photodynamic therapy (PDT). Considering commercialization or clinical app...

    Authors: Jihwan Son, Gawon Yi, Moon-Hwa Kwak, Seung Mok Yang, Jae Myung Park, Bo-In Lee, Myung-Gyu Choi and Heebeom Koo
    Citation: Journal of Nanobiotechnology 2019 17:50
  43. The increasing use of gold nanoparticles (AuNPs) in the field of neuroscience instilled hope for their rapid translation to the clinical practice. AuNPs can be engineered to carry therapeutics or diagnostics i...

    Authors: Antonello Spinelli, Maria Girelli, Daniela Arosio, Laura Polito, Paola Podini, Gianvito Martino, Pierfausto Seneci, Luca Muzio and Andrea Menegon
    Citation: Journal of Nanobiotechnology 2019 17:49
  44. Nanoparticles (NPs) are atomic clusters of crystalline or amorphous structure that possess unique physical and chemical properties associated with a size range of between 1 and 100 nm. Their nano-sized dimensi...

    Authors: Magdalena Bamburowicz-Klimkowska, Magdalena Poplawska and Ireneusz P. Grudzinski
    Citation: Journal of Nanobiotechnology 2019 17:48
  45. Glioma is a common brain tumor with a high mortality rate. A small population of cells expressing stem-like cell markers in glioma contributes to drug resistance and tumor recurrence.

    Authors: Xiaofan Zeng, Qi Wang, Xuan Tan, Le Jia, Yuwei Li, Mingdi Hu, Zhijie Zhang, Xicheng Bai, Yanhong Zhu and Xiangliang Yang
    Citation: Journal of Nanobiotechnology 2019 17:47

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