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  1. The successful deliveries of siRNA depend on their stabilities under physiological conditions because greater in vivo stability enhances cellular uptake and enables endosomal escape. Viral-based systems appear...

    Authors: Aena Yi, Dahye Sim, Young-Jin Lee, Vijaya Sarangthem and Rang-Woon Park

    Citation: Journal of Nanobiotechnology 2020 18:15

    Content type: Research

    Published on:

  2. In orthopedics, the treatment of implant-associated infections represents a high challenge. Especially, potent antibacterial effects at implant surfaces can only be achieved by the use of high doses of antibio...

    Authors: Hilke Catherina Janßen, Nina Angrisani, Stefan Kalies, Florian Hansmann, Manfred Kietzmann, Dawid Peter Warwas, Peter Behrens and Janin Reifenrath

    Citation: Journal of Nanobiotechnology 2020 18:14

    Content type: Research

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  3. During the past few decades, drug delivery system (DDS) has attracted many interests because it could enhance the therapeutic effects of drugs and reduce their side effects. The advent of nanotechnology has pr...

    Authors: Ming Gao, Yifeng Yang, Andreas Bergfel, Lanli Huang, Li Zheng and Tim Melander Bowden

    Citation: Journal of Nanobiotechnology 2020 18:13

    Content type: Research

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  4. CD47, the integrin-related protein, plays an important role in immune resistance and escape of tumor cells. Antibodies blocking the CD47/SIRPα signal pathway can effectively stimulate macrophage-mediated phago...

    Authors: Linlin Ma, Min Zhu, Junwei Gai, Guanghui Li, Qing Chang, Peng Qiao, Longlong Cao, Wanqing Chen, Siyuan Zhang and Yakun Wan

    Citation: Journal of Nanobiotechnology 2020 18:12

    Content type: Research

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  5. In several years ago, infection with human papillomaviruses (HPVs), have been prevalent in the worlds especially HPV type 18, can lead to cervical cancer. Therefore, rapid, accurate, and early diagnosis of HPV...

    Authors: Pegah Mahmoodi, Majid Rezayi, Elisa Rasouli, Amir Avan, Mehrdad Gholami, Majid Ghayour Mobarhan, Ehsan Karimi and Yatima Alias

    Citation: Journal of Nanobiotechnology 2020 18:11

    Content type: Research

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  6. 5-Fluorouracil (5-FU) has been commonly prescribed for patients with colorectal cancer (CRC), but resistance to 5-FU is one of the main reasons for failure in CRC. Recently, microRNAs (miRNAs) have been establ...

    Authors: Gaofeng Liang, Yanliang Zhu, Doulathunnisa Jaffar Ali, Tian Tian, Huantian Xu, Ke Si, Bo Sun, Baoan Chen and Zhongdang Xiao

    Citation: Journal of Nanobiotechnology 2020 18:10

    Content type: Research

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  7. The vascular system, which transports oxygen and nutrients, plays an important role in wound healing, cardiovascular disease treatment and bone tissue engineering. Angiogenesis is a complex and delicate regula...

    Authors: Wenjing Liu, Guilan Zhang, Junrong Wu, Yanli Zhang, Jia Liu, Haiyun Luo and Longquan Shao

    Citation: Journal of Nanobiotechnology 2020 18:9

    Content type: Review

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  8. Chemotherapeutic drugs frequently encounter multidrug resistance. ATP from mitochondria helps overexpression of drug efflux pumps to induce multidrug resistance, so mitochondrial delivery as a means of “repurp...

    Authors: He Wang, Fangke Zhang, Huaying Wen, Wenwen Shi, Qiudi Huang, Yugang Huang, Jiacui Xie, Peiyin Li, Jianhai Chen, Linghao Qin and Yi Zhou

    Citation: Journal of Nanobiotechnology 2020 18:8

    Content type: Research

    Published on:

  9. Antibodies are an important reagent to determine the specificity and accuracy of diagnostic immunoassays for various diseases. However, traditional antibodies have several shortcomings due to their limited abu...

    Authors: Qizhong Lu, Xiaoxuan Li, Jiakai Zhao, Jiahong Zhu, Yuhang Luo, Hong Duan, Pinpin Ji, Kun Wang, Baoyuan Liu, Xueting Wang, Wenqi Fan, Yani Sun, En-Min Zhou and Qin Zhao

    Citation: Journal of Nanobiotechnology 2020 18:7

    Content type: Research

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  10. Haptoglobin is an acute-phase protein used as predicting diagnostic biomarker both in humans (i.e., diabetes, ovarian cancer, some neurological and cardiovascular disorders) and in animals (e.g., bovine mastit...

    Authors: Narsingh R. Nirala, Yifat Harel, Jean-Paul Lellouche and Giorgi Shtenberg

    Citation: Journal of Nanobiotechnology 2020 18:6

    Content type: Research

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  11. Lipid nanocapsules (LNCs) are promising vehicles for drug delivery. However, since not much was known about cellular toxicity of these nanoparticles in themselves, we have here investigated the mechanisms invo...

    Authors: Marzena Szwed, Maria Lyngaas Torgersen, Remya Valsala Kumari, Sunil Kumar Yadava, Sascha Pust, Tore Geir Iversen, Tore Skotland, Jyotsnendu Giri and Kirsten Sandvig

    Citation: Journal of Nanobiotechnology 2020 18:5

    Content type: Research

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  12. Disulfiram (DSF) has been considered as “Repurposing drug” in cancer therapy in recent years based on its good antitumor efficacy. DSF is traditionally used as an oral drug in the treatment of alcoholism. To o...

    Authors: Haowen Li, Biao Liu, Hui Ao, Jingxin Fu, Yian Wang, Yue Feng, Yifei Guo and Xiangtao Wang

    Citation: Journal of Nanobiotechnology 2020 18:4

    Content type: Research

    Published on:

  13. Nanotechnology-based therapeutic approaches have attracted attention of scientists, in particular due to the special features of nanomaterials, such as adequate biocompatibility, ability to improve therapeutic...

    Authors: Urszula Wnorowska, Krzysztof Fiedoruk, Ewelina Piktel, Suhanya V. Prasad, Magdalena Sulik, Marianna Janion, Tamara Daniluk, Paul B. Savage and Robert Bucki

    Citation: Journal of Nanobiotechnology 2020 18:3

    Content type: Review

    Published on:

  14. After publication of this article, an error was found in the description of the holmium isotopes. 165Ho is a stable isotope a fraction of which is activated to 166Ho by neutron activation in a nuclear reactor [2]...

    Authors: Oleksii O. Peltek, Albert R. Muslimov, Mikhail V. Zyuzin and Alexander S. Timin

    Citation: Journal of Nanobiotechnology 2020 18:2

    Content type: Correction

    Published on:

    The original article was published in Journal of Nanobiotechnology 2019 17:90

  15. Photoimmunotherapy involves targeted delivery of photosensitizers via an antibody conjugate (i.e., photoimmunoconjugate, PIC) followed by light activation for selective tumor killing. The trade-off between PIC...

    Authors: Barry J. Liang, Michael Pigula, Yan Baglo, Daniel Najafali, Tayyaba Hasan and Huang-Chiao Huang

    Citation: Journal of Nanobiotechnology 2020 18:1

    Content type: Research

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  16. An important but rarely addressed question in nano-therapy is to know whether bio-degraded nanoparticles with reduced sizes and weakened heating power are able to maintain sufficient anti-tumor activity to ful...

    Authors: Edouard Alphandéry, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, Florence Gazeau, François Guyot and Imène Chebbi

    Citation: Journal of Nanobiotechnology 2019 17:126

    Content type: Research

    Published on:

  17. Multidrug resistance (MDR) is a pressing obstacle in clinical chemotherapy for breast cancer. Based on the fact that the drug efflux is an important factor in MDR, we designed a codelivery system to guide the ...

    Authors: Yang Dong, Hongze Liao, Jian Yu, Hao Fu, De Zhao, Ke Gong, Qi Wang and Yourong Duan

    Citation: Journal of Nanobiotechnology 2019 17:125

    Content type: Research

    Published on:

  18. Understanding the in vivo size-dependent pharmacokinetics and toxicity of nanoparticles is crucial to determine their successful development. Systematic studies on the size-dependent biological effects of nano...

    Authors: Jinquan Li, Zhongxue Yuan, Huili Liu, Jianghua Feng and Zhong Chen

    Citation: Journal of Nanobiotechnology 2019 17:124

    Content type: Research

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  19. Nanomedicine is a promising new approach to cancer treatment that avoids the disadvantages of traditional chemotherapy and improves therapeutic indices. However, the lack of a real-time visualization imaging t...

    Authors: Yanlong Jia, Chaochao Wang, Jiehua Zheng, Guisen Lin, Dalong Ni, Zhiwei Shen, Baoxuan Huang, Yan Li, Jitian Guan, Weida Hong, Yuanfeng Chen and Renhua Wu

    Citation: Journal of Nanobiotechnology 2019 17:123

    Content type: Research

    Published on:

  20. Obesity through its association with type 2 diabetes (T2D), cancer and cardiovascular diseases (CVDs), poses a serious health threat, as these diseases contribute to high mortality rates. Pharmacotherapy alone...

    Authors: Nicole Remaliah Samantha Sibuyi, Koena Leah Moabelo, Mervin Meyer, Martin Opiyo Onani, Admire Dube and Abram Madimabe Madiehe

    Citation: Journal of Nanobiotechnology 2019 17:122

    Content type: Review

    Published on:

  21. DNA methylation detection is indispensable for the diagnosis and prognosis of various diseases including malignancies. Hence, it is crucial to develop a simple, sensitive, and specific detection strategy.

    Authors: Shu Zhang, Jian Huang, Jingrun Lu, Min Liu, Yan Li, Lichao Fang, Hui Huang, Jianjun Huang, Fei Mo and Junsong Zheng

    Citation: Journal of Nanobiotechnology 2019 17:121

    Content type: Research

    Published on:

  22. Tamoxifen (Tam) is the most frequent treatment for estrogen receptor (ER) positive breast cancer. We recently showed that fibronectin (FN) leads to Tam resistance and selection of breast cancer stem cells. Wit...

    Authors: María Inés Diaz Bessone, Lorena Simón-Gracia, Pablo Scodeller, María de los Angeles Ramirez, María Amparo Lago Huvelle, Galo J. A. A. Soler-Illia and Marina Simian

    Citation: Journal of Nanobiotechnology 2019 17:120

    Content type: Research

    Published on:

  23. The functional preservation of the central nervous system (CNS) is based on the neuronal plasticity and survival. In this context, the neuroinflammatory state plays a key role and involves the microglial cells...

    Authors: Quentin Lemaire, Antonella Raffo-Romero, Tanina Arab, Christelle Van Camp, Francesco Drago, Stefano Forte, Jean-Pascal Gimeno, Séverine Begard, Morvane Colin, Jacopo Vizioli, Pierre-Eric Sautière, Michel Salzet and Christophe Lefebvre

    Citation: Journal of Nanobiotechnology 2019 17:119

    Content type: Research

    Published on:

  24. Developing new strategies to reduce the output power of microwave (MW) ablation while keeping anti-tumor effect are highly desirable for the simultaneous achievement of effective tumor killing and avoidance of...

    Authors: Jian-ping Dou, Qiong Wu, Chang-hui Fu, Dong-yun Zhang, Jie Yu, Xian-wei Meng and Ping Liang

    Citation: Journal of Nanobiotechnology 2019 17:118

    Content type: Research

    Published on:

  25. Cancer cells always develop ways to resist and evade chemotherapy. To overcome this obstacle, herein, we introduce a programmatic release drug delivery system that imparts avoiding drug efflux and nuclear tran...

    Authors: Yanyan Li, Yongxia Zhai, Wei Liu, Kaixiang Zhang, Junjie Liu, Jinjin Shi and Zhenzhong Zhang

    Citation: Journal of Nanobiotechnology 2019 17:117

    Content type: Research

    Published on:

  26. Tumor cells with heterogeneity and diversity can express different markers. At present, positive separation of circulating tumor cells (CTC) taking EpCAM as the marker was used in most cases which could be one...

    Authors: Jingde Chen, Lin Chen, Shibin Du, Jing Wu, Ming Quan, Hua Yin, Yin Wu, Xuanting Ye, Xiaofei Liang and Hong Jiang

    Citation: Journal of Nanobiotechnology 2019 17:116

    Content type: Review

    Published on:

  27. We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of Cl...

    Authors: Beatrice Formicola, Roberta Dal Magro, Carlos V. Montefusco-Pereira, Claus-Michael Lehr, Marcus Koch, Laura Russo, Gianvito Grasso, Marco A. Deriu, Andrea Danani, Sandrine Bourdoulous and Francesca Re

    Citation: Journal of Nanobiotechnology 2019 17:115

    Content type: Short Communication

    Published on:

  28. The biological activity of MXenes has been studied for several years because of their potential biomedical applications; however, investigations have so far been limited to 2D titanium carbides. Although monol...

    Authors: A. Szuplewska, A. Rozmysłowska-Wojciechowska, S. Poźniak, T. Wojciechowski, M. Birowska, M. Popielski, M. Chudy, W. Ziemkowska, L. Chlubny, D. Moszczyńska, A. Olszyna, J. A. Majewski and A. M. Jastrzębska

    Citation: Journal of Nanobiotechnology 2019 17:114

    Content type: Research

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  29. Synergistic therapy of tumor is a promising way in curing cancer and in order to achieve effective tumor therapy with real-time drug release monitoring, dynamic cellular imaging and antitumor activity.

    Authors: Chen Du, Yan Liang, Qingming Ma, Qianwen Sun, Jinghui Qi, Jie Cao, Shangcong Han, Mingtao Liang, Bo Song and Yong Sun

    Citation: Journal of Nanobiotechnology 2019 17:113

    Content type: Research

    Published on:

  30. Cerium oxide nanoparticles are effective scavengers of reactive oxygen species and have been proposed as a treatment for oxidative stress-related diseases. Consequently, we aimed to investigate the effect of t...

    Authors: Bernat Córdoba-Jover, Altamira Arce-Cerezo, Jordi Ribera, Montse Pauta, Denise Oró, Gregori Casals, Guillermo Fernández-Varo, Eudald Casals, Victor Puntes, Wladimiro Jiménez and Manuel Morales-Ruiz

    Citation: Journal of Nanobiotechnology 2019 17:112

    Content type: Research

    Published on:

  31. Triple negative breast cancer (TNBC) has the poorest prognosis of all breast cancer subtypes and is one of the most fatal diseases for women. Combining cytotoxic chemotherapy with immunotherapy has shown great...

    Authors: Shen-Jun Yuan, Yong-Hong Xu, Chao Wang, Hui-Chao An, Hua-Zhen Xu, Ke Li, Naoki Komatsu, Li Zhao and Xiao Chen

    Citation: Journal of Nanobiotechnology 2019 17:110

    Content type: Research

    Published on:

  32. Multidrug resistance (MDR) generally leads to breast cancer treatment failure. The most common mechanism of MDR is the overexpression of ATP-binding cassette (ABC) efflux transporters such as P-glycoprotein (P...

    Authors: Sipei Zhang, Nan Guo, Guoyun Wan, Tao Zhang, Chunyu Li, Yongfei Wang, Yinsong Wang and Yuanyuan Liu

    Citation: Journal of Nanobiotechnology 2019 17:109

    Content type: Research

    Published on:

  33. A major bottleneck in drug delivery is the breakdown and degradation of the delivery system through the endosomal/lysosomal network of the host cell, hampering the correct delivery of the drug of interest. In ...

    Authors: Ismael Plaza-GA, Vanesa Manzaneda-González, Matic Kisovec, Víctor Almendro-Vedia, Mónica Muñoz-Úbeda, Gregor Anderluh, Andrés Guerrero-Martínez, Paolo Natale and Iván López Montero

    Citation: Journal of Nanobiotechnology 2019 17:108

    Content type: Research

    Published on:

  34. New nanophotosensitizers for photothermal cancer therapy (PTT) are still sought. In this paper we propose fancy shaped, non agglomerated core/shell PtAu NRs nanoraspberries (PtAu NRs) as potential nanophotosen...

    Authors: J. Depciuch, M. Stec, B. Klebowski, J. Baran and M. Parlinska-Wojtan

    Citation: Journal of Nanobiotechnology 2019 17:107

    Content type: Research

    Published on:

  35. Improving the water solubility of hydrophobic drugs, increasing their accumulation in tumor tissue and allowing their simultaneous action by different pathways are essential issues for a successful chemotherap...

    Authors: E. Villar-Alvarez, A. Cambón, A. Pardo, L. Arellano, A. V. Marcos, B. Pelaz, P. del Pino, A. Bouzas Mosquera, V. X. Mosquera, A. Almodlej, G. Prieto, S. Barbosa and P. Taboada

    Citation: Journal of Nanobiotechnology 2019 17:106

    Content type: Research

    Published on:

  36. To develop a novel fluorine-18 (18F)-labeled arginine–glycine–aspartic acid (RGD)-coupled ultra-small iron oxide nanoparticle (USPIO) (hereafter, referred to as 18F-RGD@USPIO) and conduct an in-depth investigatio...

    Authors: Yanshu Wang, Huanhuan Liu, Defan Yao, Jinning Li, Shuyan Yang, Caiyuan Zhang, Weibo Chen and Dengbin Wang

    Citation: Journal of Nanobiotechnology 2019 17:105

    Content type: Research

    Published on:

  37. Efficient and highly controllable antibacterial effect, as well as good biocompatibility are required for antibacterial materials to overcome multi-drug resistance in bacteria. Herein, nano graphene oxide (NGO...

    Authors: Yongxin Zhang, Hao Fu, De-E Liu, Jinxia An and Hui Gao

    Citation: Journal of Nanobiotechnology 2019 17:104

    Content type: Research

    Published on:

  38. Immunocompromised individuals and those with lung dysfunction readily acquire pulmonary bacterial infections, which may cause serious diseases and carry a heavy economic burden. Maintaining adequate antibiotic...

    Authors: Yu Wang, Qian Yuan, Wei Feng, Wendan Pu, Jun Ding, Hongjun Zhang, Xiaoyu Li, Bo Yang, Qing Dai, Lin Cheng, Jinyu Wang, Fengjun Sun and Dinglin Zhang

    Citation: Journal of Nanobiotechnology 2019 17:103

    Content type: Research

    Published on:

  39. Natural extracellular matrices (ECMs) are three-dimensional (3D) and multi-scale hierarchical structure. However, coatings used as ECM-mimicking structures for osteogenesis are typically two-dimensional or sin...

    Authors: Mengfei Yu, Yu Liu, Xiaowen Yu, Jianhua Li, Wenquan Zhao, Ji’an Hu, Kui Cheng, Wenjian Weng, Bin Zhang, Huiming Wang and Lingqing Dong

    Citation: Journal of Nanobiotechnology 2019 17:102

    Content type: Research

    Published on:

  40. Diverse properties of graphenic materials have been extensively explored to determine properties that make good electrochemical nanomaterial-based biosensors. These are reviewed by critically examining the inf...

    Authors: Teddy Tite, Elena Alina Chiticaru, Jorge S. Burns and Mariana Ioniţă

    Citation: Journal of Nanobiotechnology 2019 17:101

    Content type: Review

    Published on:

  41. Pesticides and fertilizers are widely used to enhance agriculture yields, although the fraction of the pesticides applied in the field that reaches the targets is less than 0.1%. Such indiscriminate use of che...

    Authors: Marcela Candido Camara, Estefânia Vangelie Ramos Campos, Renata Aparecida Monteiro, Anderson do Espirito Santo Pereira, Patrícia Luiza de Freitas Proença and Leonardo Fernandes Fraceto

    Citation: Journal of Nanobiotechnology 2019 17:100

    Content type: Review

    Published on:

  42. Combined therapy has demonstrated to be an effective strategy for cancer therapy. Herein, an injectable hydrogel based on the genetically engineered polypeptide and hollow gold nanoshells (HAuNS) has been deve...

    Authors: RuiMei Jin, Jie Yang, DongHui Zhao, XiaoLin Hou, ChaoQing Li, Wei Chen, YuanDi Zhao, ZhongYuan Yin and Bo Liu

    Citation: Journal of Nanobiotechnology 2019 17:99

    Content type: Research

    Published on:

  43. The authors apologized for the unfortunate error in figure during publication of the article and they also explained that some of the solid grey graphs in Fig. 5 are intentionally based on the same data. For 8...

    Authors: Philipp Nold, Raimo Hartmann, Neus Feliu, Karsten Kantner, Mahmoud Gamal, Beatriz Pelaz, Jonas Hühn, Xing Sun, Philipp Jungebluth, Pablo del Pino, Holger Hackstein, Paolo Macchiarini, Wolfgang J. Parak and Cornelia Brendel

    Citation: Journal of Nanobiotechnology 2019 17:98

    Content type: Correction

    Published on:

    The original article was published in Journal of Nanobiotechnology 2017 15:24

  44. Porcine epidemic diarrhea virus (PEDV), which is characterized by severe watery diarrhea, vomiting, dehydration and a high mortality rate in piglets, leads to enormous economic losses to the pork industry and ...

    Authors: Zhiqian Ma, Tianyu Wang, Zhiwei Li, Xuyang Guo, Yangsheng Tian, Yang Li and Shuqi Xiao

    Citation: Journal of Nanobiotechnology 2019 17:96

    Content type: Research

    Published on:

  45. It is extremely difficult to develop targeted treatments for triple-negative breast (TNB) cancer, because these cells do not express any of the key biomarkers usually exploited for this goal.

    Authors: Shiwei Niu, Gareth R. Williams, Jianrong Wu, Junzi Wu, Xuejing Zhang, Xia Chen, Shude Li, Jianlin Jiao and Li-Min Zhu

    Citation: Journal of Nanobiotechnology 2019 17:95

    Content type: Research

    Published on:

  46. The persistence, biodistribution, and risk of integration into the host genome of any new therapeutic DNA vaccine must be established in preclinical studies. We previously developed the DNA vaccine pcDNA-CCOL2A1 ...

    Authors: Xiao Zhao, Juan Long, Fei Liang, Nan Liu, Yuying Sun and Yongzhi Xi

    Citation: Journal of Nanobiotechnology 2019 17:94

    Content type: Research

    Published on:

  47. Exosomes (Exo) hold great promise as endogenous nanocarriers that can deliver biological information between cells. However, Exo are limited in terms of their abilities to target specific recipient cell types....

    Authors: Chunai Gong, Jing Tian, Zhuo Wang, Yuan Gao, Xin Wu, Xueying Ding, Lei Qiang, Guorui Li, Zhimin Han, Yongfang Yuan and Shen Gao

    Citation: Journal of Nanobiotechnology 2019 17:93

    Content type: Research

    Published on:

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