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  1. Ulcerative colitis (UC) is a major type of inflammatory bowel disease (IBD), which could induce bloody stool, diarrhea, colon atrophy and eventually lead to colorectal cancer. The conventional daily oral admin...

    Authors: Meng Gao, Chen Yang, Chenghu Wu, Yue Chen, Hongqin Zhuang, Jilong Wang and Zhiting Cao
    Citation: Journal of Nanobiotechnology 2022 20:404
  2. 7-p-trifluoromethylphenyl-FL118 (FLQY2) is a camptothecin analog with excellent antitumor efficacy against various solid tumors. However, its poor solubility and low bioavailability limited the development of ...

    Authors: Yi Wang, Wenchao Wang, Endian Yu, Wenya Zhuang, Xuanrong Sun, Hong Wang and Qingyong Li
    Citation: Journal of Nanobiotechnology 2022 20:402
  3. Sepsis is caused mainly by infection in the blood with a broad range of bacterial species. It can be diagnosed by molecular diagnostics once compounds in the blood that interfere with molecular diagnostics are...

    Authors: Abdurhaman Teyib Abafogi, Tepeng Wu, Daekyu Lee, Jinyeop Lee, Gyoujin Cho, Luke P. Lee and Sungsu Park
    Citation: Journal of Nanobiotechnology 2022 20:400
  4. Effective therapeutics and vaccines for coronavirus disease 2019 (COVID-19) are currently lacking because of the mutation and immune escape of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Base...

    Authors: Xiaoli Wu, Junye Liu, Hongpeng Zhang, Hua Zhou, Wen Wang, Yuanyan Ma, Shimei Shen, Xuefei Cai, Ailong Huang and Deqiang Wang
    Citation: Journal of Nanobiotechnology 2022 20:399
  5. The ideal neural interface or scaffold for stem cell therapy shall have good biocompatibility promoting survival, maturation and integration of neural stem cells (NSCs) in targeted brain regions. The unique el...

    Authors: Yige Li, Yangnan Hu, Hao Wei, Wei Cao, Yanru Qi, Shan Zhou, Panpan Zhang, Huawei Li, Geng-Lin Li and Renjie Chai
    Citation: Journal of Nanobiotechnology 2022 20:398
  6. Ischemic stroke is one of the most serious global public health problems. However, the performance of current therapeutic regimens is limited due to their poor target specificity, narrow therapeutic time windo...

    Authors: Ranran Duan, Ke Sun, Fang Fang, Ning Wang, Ruya He, Yang Gao, Lijun Jing, Yanfei Li, Zhe Gong, Yaobing Yao, Tingting Luan, Chaopeng Zhang, Jinwei Zhang, Yi Zhao, Haojie Xie, Yongyan Zhou…
    Citation: Journal of Nanobiotechnology 2022 20:397
  7. The abnormal expression of long non-coding RNAs (LncRNAs) in platelet-derived microparticles (PMPs) is closely related to immune disorders and may lead to antiphospholipid antibody syndrome and recurrent misca...

    Authors: Zhiwei Sun, Qian Zhou, Yufei Yang, Lei Li, Mengru Yu, Hui Li, Aihua Li, Xietong Wang and Yanyan Jiang
    Citation: Journal of Nanobiotechnology 2022 20:396
  8. The rapid advancement of nanomedicine and nanoparticle (NP) materials presents novel solutions potentially capable of revolutionizing health care by improving efficacy, bioavailability, drug targeting, and saf...

    Authors: Saquib Waheed, Zhibin Li, Fangyingnan Zhang, Anna Chiarini, Ubaldo Armato and Jun Wu
    Citation: Journal of Nanobiotechnology 2022 20:395
  9. Epithelial-mesenchymal transition (EMT), a differentiation process with aberrant changes of tumor cells, is identified as an initial and vital procedure for metastatic processes. Inflammation is a significant ...

    Authors: Tianze Jiang, Laozhi Xie, Songlei Zhou, Yipu Liu, Yukun Huang, Ni Mei, Fenfen Ma, Jingru Gong, Xiaoling Gao and Jun Chen
    Citation: Journal of Nanobiotechnology 2022 20:394
  10. High-quality point-of-care is critical for timely decision of disease diagnosis and healthcare management. In this regard, biosensors have revolutionized the field of rapid testing and screening, however, are ...

    Authors: Sabyasachi Dash, Tuhin Das, Paritosh Patel, Pritam Kumar Panda, Mrutyunjay Suar and Suresh K. Verma
    Citation: Journal of Nanobiotechnology 2022 20:393
  11. Injuries to the urethra can be caused by malformations, trauma, inflammation, or carcinoma, and reconstruction of the injured urethra is still a significant challenge in clinical urology. Implanting grafts for...

    Authors: Qinyuan Tan, Hanxiang Le, Chao Tang, Ming Zhang, Weijie Yang, Yazhao Hong and Xiaoqing Wang
    Citation: Journal of Nanobiotechnology 2022 20:392
  12. Cancer nanomedicines based on synthetic polypeptides have attracted much attention due to their superior biocompatibility and biodegradability, stimuli responsive capability through secondary conformation chan...

    Authors: Maliheh Hasannia, Khalil Abnous, Seyed Mohammad Taghdisi, Sirous Nekooei, Mohammad Ramezani and Mona Alibolandi
    Citation: Journal of Nanobiotechnology 2022 20:391
  13. Abundant glutathione (GSH) is a biological characteristic of lots of tumor cells. A growing number of studies are utilizing GSH depletion as an effective adjuvant therapy for tumor. However, due to the compens...

    Authors: Yang Gao, Yun Li, Hongmei Cao, Haixue Jia, Dianyu Wang, Chunhua Ren, Zhongyan Wang, Cuihong Yang and Jianfeng Liu
    Citation: Journal of Nanobiotechnology 2022 20:390
  14. Dysregulated mucosal immune responses and colonic fibrosis impose two formidable challenges for ulcerative colitis treatment. It indicates that monotherapy could not sufficiently deal with this complicated dis...

    Authors: Jiaxin Zhang, Ante Ou, Xueping Tang, Rong Wang, Yujuan Fan, Yuefei Fang, Yuge Zhao, Pengfei Zhao, Dongying Chen, Bing Wang and Yongzhuo Huang
    Citation: Journal of Nanobiotechnology 2022 20:389
  15. The anticancer treatment is largely affected by the microenvironment of the tumors, which not only resists the tumors to the thermo/chemo-therapy, but also promotes their growth and invasion. In this work, the...

    Authors: Ying Zhang, Jingyao Zhu, Zheng Zhang, Dannong He, Jun Zhu, Yunsheng Chen and Yixin Zhang
    Citation: Journal of Nanobiotechnology 2022 20:388
  16. The plant toxin ricin, especially its cytotoxic A chain (RTA), can be genetically engineered with targeting ligands to develop specific anti-cancer recombinant immunotoxins (RITs). Here, we used affibody molec...

    Authors: Seong Guk Park, Heeyeon Kim, Heejin Jun, Sun Young Choi, Eunhee Kim and Sebyung Kang
    Citation: Journal of Nanobiotechnology 2022 20:387
  17. The colonization of bacterial pathogens is a major concern in wound infection and becoming a public health issue. Herein, a core–shell structured Ag@MSN (silver core embedded with mesoporous silica, AM)-based ...

    Authors: Qiqi Liu, Ying Zhang, Jingkai Huang, Zhourui Xu, Xiang Li, Jingyu Yang, Haoqiang Huang, Shiqi Tang, Yujuan Chai, Jinbo Lin, Chengbin Yang, Jia Liu and Suxia Lin
    Citation: Journal of Nanobiotechnology 2022 20:386
  18. Exosomes are recognized as effective platforms for targeted delivery for their high physicochemical stability and biocompatibility. However, most of the exosomes are inevitably and rapidly cleared by mononucle...

    Authors: Zhuo Wan, Xueqi Gan, Ruiyan Mei, Jianbin Du, Wen Fan, Mengying Wei, Guodong Yang, Weiwei Qin, Zhuoli Zhu and Li Liu
    Citation: Journal of Nanobiotechnology 2022 20:385
  19. Melanoma is the most malignant skin tumor and is difficult to cure with the alternative treatments of chemotherapy, biotherapy, and immunotherapy. Our previous study showed that triptolide (TP) exhibited powerful...

    Authors: Yongwei Gu, Yue Du, Liangdi Jiang, Xiaomeng Tang, Aixue Li, Yunan Zhao, Yitian Lang, Xiaoyan Liu and Jiyong Liu
    Citation: Journal of Nanobiotechnology 2022 20:384
  20. Bioactive materials have been extensively developed for the adjuvant therapy of cancer. However, few materials can meet the requirements for the postoperative resection of hepatocellular carcinoma (HCC) due to...

    Authors: Sheng Chen, Yonghong Song, Xu Yan, Liang Dong, Yunjun Xu, Shouhu Xuan, Quan Shu, Baoqiang Cao, Jinlong Hu, Hanye Xing, Wenshu Wu, Zhengbao Zha and Yang Lu
    Citation: Journal of Nanobiotechnology 2022 20:381
  21. Innate immunity is the first line of defense against invading pathogens. Innate immune cells can recognize invading pathogens through recognizing pathogen-associated molecular patterns (PAMPs) via pattern reco...

    Authors: Chung-Nga Ko, Shaohong Zang, Yingtang Zhou, Zhangfeng Zhong and Chao Yang
    Citation: Journal of Nanobiotechnology 2022 20:380
  22. Disruption of the postsynaptic density protein-95 (PSD95)—neuronal nitric oxide synthase (nNOS) coupling is an effective way to treat ischemic stroke, however, it still faces some challenges, especially lack o...

    Authors: Yingying Ding, Yang Jin, Tao Peng, Yankun Gao, Yang Zang, Hongliang He, Fei Li, Yu Zhang, Hongjuan Zhang and Lina Chen
    Citation: Journal of Nanobiotechnology 2022 20:379
  23. Low-intensity pulsed ultrasound (LIPUS) has been reported to accelerate fracture healing, but the mechanism is unclear and its efficacy needs to be further optimized. Ultrasound in combination with functionali...

    Authors: Huan Yao, Liang Zhang, Shujin Yan, Yiman He, Hui Zhu, Yasha Li, Dong Wang and Ke Yang
    Citation: Journal of Nanobiotechnology 2022 20:378
  24. Type 1 diabetes mellitus (T1DM) is an autoimmune disease mediated by autoreactive T cells and dominated by Th1 response polarization. Insulin replacement therapy faces great challenges to this autoimmune disea...

    Authors: Haoming Huang, Dian Hu, Zhuo Chen, Jiarong Xu, Rengui Xu, Yusheng Gong, Zhengming Fang, Ting Wang and Wei Chen
    Citation: Journal of Nanobiotechnology 2022 20:377
  25. Breast cancer is the leading cause of cancer-related deaths in women and remains a formidable therapeutic challenge. Mitochondria participate in a myriad of essential cellular processes, such as metabolism, an...

    Authors: Liwei Gu, Jiaxing Zhang, Dandan Liu, Jiayun Chen, Shuzhi Liu, Qing Peng, Ya Tian, Maobo Du, Junzhe Zhang, Wei Xiao, Shuo Shen and Jigang Wang
    Citation: Journal of Nanobiotechnology 2022 20:376
  26. Given the spasmodic increment in antimicrobial resistance (AMR), world is on the verge of “post-antibiotic era”. It is anticipated that current SARS-CoV2 pandemic would worsen the situation in future, mainly d...

    Authors: Nayanika Chakraborty, Diksha Jha, Indrajit Roy, Pradeep Kumar, Shailendra Singh Gaurav, Kalisvar Marimuthu, Oon-Tek Ng, Rajamani Lakshminarayanan, Navin Kumar Verma and Hemant K. Gautam
    Citation: Journal of Nanobiotechnology 2022 20:375
  27. Ovarian aging is characterized by a progressive decline in ovarian function. With the increase in life expectancy worldwide, ovarian aging has gradually become a key health problem among women. Over the years,...

    Authors: Meng Wu, Yican Guo, Simin Wei, Liru Xue, Weicheng Tang, Dan Chen, Jiaqiang Xiong, Yibao Huang, Fangfang Fu, Chuqing Wu, Ying Chen, Su Zhou, Jinjin Zhang, Yan Li, Wenwen Wang, Jun Dai…
    Citation: Journal of Nanobiotechnology 2022 20:374
  28. The escape of bladder cancer from immunosurveillance causes monotherapy to exhibit poor efficacy; therefore, designing a multifunctional nanoparticle that boosts programmed cell death and immunoactivation has ...

    Authors: Yu-Cheng Chin, Li-Xing Yang, Fei-Ting Hsu, Che-Wei Hsu, Te-Wei Chang, Hsi-Ying Chen, Linda Yen-Chien Chen, Zi Chun Chia, Chun-Hua Hung, Wu-Chou Su, Yi-Chun Chiu, Chih-Chia Huang and Mei-Yi Liao
    Citation: Journal of Nanobiotechnology 2022 20:373
  29. Although combination chemoimmunotherapy shows promising clinical results for cancer treatment, this approach is largely restricted by variable objective response rate and severe systemic adverse effects of imm...

    Authors: Jun Gu, Gang Zhao, Jiangkun Yu, Pei Xu, Jiabin Yan, Zhengshuai Jin, Sheng Chen, Yong Wang, Leshuai W. Zhang and Yangyun Wang
    Citation: Journal of Nanobiotechnology 2022 20:372
  30. Colorectal cancer is considered one of the major malignancies that threaten the lives and health of people around the world. Patients with CRC are prone to post-operative local recurrence or metastasis, and so...

    Authors: Yu Guo, Min Wang, Yongbo Zou, Longhai Jin, Zeyun Zhao, Qi Liu, Shuang Wang and Jiannan Li
    Citation: Journal of Nanobiotechnology 2022 20:371
  31. Small extracellular vesicles (sEVs) are an important component in the paracrine pathway. They can be used as a substitute for seed cells and have shown good application prospects in promoting bone regeneration...

    Authors: Ming Dong, Chun Shi, Xinxin Yu, Qian Yang, Saixuan Wu, Runyuan Liu, Tingjiao Liu, Lina Wang and Weidong Niu
    Citation: Journal of Nanobiotechnology 2022 20:370
  32. Immunosuppressive tumor immune microenvironment (TIME) lowers immunotherapy effectiveness. Additionally, low penetration efficiency and unpredictable drug release in tumor areas restrict tumor therapy.

    Authors: Xiaoyan Ge, Yanyun Hao, Hui Li, Huajun Zhao, Yang Liu, Yutong Liu, Xia Li, Hongfei Chen, Jing Zou, Shiying Zhang, Lingling Huang, Gang Shan and Zhiyue Zhang
    Citation: Journal of Nanobiotechnology 2022 20:369
  33. Developing highly efficient pharmaceuticals to eradicate pathogens and facilitate wound healing is of great concern. Despite some cationic carbon dots (CDs) have been used for sterilization, hardly any anionic...

    Authors: Chengjian Mou, Xinyuan Wang, Jiahui Teng, Zhigang Xie and Min Zheng
    Citation: Journal of Nanobiotechnology 2022 20:368
  34. Astrocyte is a key regulator of neuronal activity and excitatory/inhibitory balance via gliotransmission. Recently, gliotransmission has been identified as a novel target for neurological diseases. However, us...

    Authors: Won-Seok Lee, Ji-Hye Kang, Jung-Hwan Lee, Yoo Sung Kim, Jongmin Joseph Kim, Han-Sem Kim, Hae-Won Kim, Ueon Sang Shin and Bo-Eun Yoon
    Citation: Journal of Nanobiotechnology 2022 20:367
  35. Surgery is currently a mainstream treatment modality for various solid tumor indications. However, aggressive resection of tumor tissues frequently causes postoperative complications, which severely undermine ...

    Authors: Yanhua Hou, Yang Fei, Zehong Liu, Yingqi Liu, Menghuan Li and Zhong Luo
    Citation: Journal of Nanobiotechnology 2022 20:366
  36. The failure of orthopedic and dental implants is mainly caused by biomaterial-associated infections and poor osseointegration. Surface modification of biomedical materials plays a significant role in enhancing...

    Authors: Libin Lu, Jiaru Zhang, Kai Guan, Jin Zhou, Fusong Yuan and Yingchun Guan
    Citation: Journal of Nanobiotechnology 2022 20:365
  37. Magnetosomes (BMPs) are organelles of magnetotactic bacteria (MTB) that are responsible for mineralizing iron to form magnetite. In addition, BMP is an ideal biomaterial that is widely used in bio- and nano-te...

    Authors: Junjie Xu, Shijiao Ma, Wei Zhang, Lina Jia, Haolan Zheng, Pang Bo, Xue Bai, Hongyan Sun, Lei Qi, Tongwei Zhang, Chuanfang Chen, Feng Li, Fumihito Arai, Jiesheng Tian and Lin Feng
    Citation: Journal of Nanobiotechnology 2022 20:364
  38. With the success of recent non-viral gene delivery-based COVID-19 vaccines, nanovectors have gained some public acceptance and come to the forefront of advanced therapies. Unfortunately, the relatively low abi...

    Authors: Federica Ponti, Nina Bono, Luca Russo, Paolo Bigini, Diego Mantovani and Gabriele Candiani
    Citation: Journal of Nanobiotechnology 2022 20:363

    The Correction to this article has been published in Journal of Nanobiotechnology 2022 20:489

  39. Oral delivery of therapeutics is the preferred route of administration due to ease of administration which is associated with greater patient medication adherence. One major barrier to oral delivery and intest...

    Authors: Deepak A. Subramanian, Robert Langer and Giovanni Traverso
    Citation: Journal of Nanobiotechnology 2022 20:362
  40. Ocular drug delivery is one of the most challenging endeavors among the various available drug delivery systems. Despite having suitable drugs for the treatment of ophthalmic disease, we have not yet succeeded...

    Authors: Mehrdad Afarid, Shirin Mahmoodi and Roghayyeh Baghban
    Citation: Journal of Nanobiotechnology 2022 20:361
  41. Exosomes show potential for treating patients with spinal cord injury (SCI) in clinical practice, but the underlying repair mechanisms remain poorly understood, and biological scaffolds available for clinical ...

    Authors: Xiaolie He, Li Yang, Kun Dong, Feng Zhang, Yuchen Liu, Bei Ma, Youwei Chen, Jian Hai, Rongrong Zhu and Liming Cheng
    Citation: Journal of Nanobiotechnology 2022 20:360
  42. The conversion of tumor-promoting M2 macrophage phenotype to tumor-suppressing M1 macrophages is a promising therapeutic approach for cancer treatment. However, the tumor normally provides an abundance of M2 m...

    Authors: Yongmei Zhao, Yuanlin Zheng, Yan Zhu, Hongyun Li, Hongyan Zhu and Tianqing Liu
    Citation: Journal of Nanobiotechnology 2022 20:359
  43. Laccase-based biosensors are efficient for detecting phenolic compounds. However, the instability and high cost of laccases have hindered their practical utilization.

    Authors: Thao Nguyen Le, Xuan Ai Le, Tai Duc Tran, Kang Jin Lee and Moon Il Kim
    Citation: Journal of Nanobiotechnology 2022 20:358
  44. The exosomal miRNA (exo-miRNA) derived from tumor cells contains rich biological information that can effectively aid in the early diagnosis of disease. However, the extremely low abundance imposes stringent r...

    Authors: Xin Gao, Haiping Wu, Yujian Li, Lu Zhang, Mingxuan Song, Xuhuai Fu, Rui Chen, Shijia Ding, Jiawei Zeng, Jia Li and Ping Liu
    Citation: Journal of Nanobiotechnology 2022 20:357
  45. Due to their prevalence, dental caries ranks first among all diseases endangering human health. Therefore, the prevention of caries is of great significance, as caries have become a serious public health probl...

    Authors: Luting Weng, Lang Wu, Rongjuan Guo, Jiajia Ye, Wen Liang, Wei Wu, Liang Chen and Deqin Yang
    Citation: Journal of Nanobiotechnology 2022 20:356
  46. The CRISPR-Cas9 technology has changed the landscape of genome editing and has demonstrated extraordinary potential for treating otherwise incurable diseases. Engineering strategies to enable efficient intrace...

    Authors: Tianxu Fang, Xiaona Cao, Mysha Ibnat and Guojun Chen
    Citation: Journal of Nanobiotechnology 2022 20:354
  47. Fullerenol, a functional and water-soluble fullerene derivative, plays an important role in antioxidant, antitumor and antivirus, implying its enormous potential in biomedical applications. However, the in viv...

    Authors: Yingying Zha, Yan Jin, Xinxing Wang, Lin Chen, Xulai Zhang and Ming Wang
    Citation: Journal of Nanobiotechnology 2022 20:348

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