Articles

Effects of the surface charge of polyamidoamine dendrimers on cellular exocytosis and the exocytosis mechanism in multidrug-resistant breast cancer cells

Polyamidoamine (PAMAM) dendrimer applications have extended from tumor cells to multidrug-resistant tumor cells. However, their transportation in multidrug-resistant tumor cells remains unclear. Herein, we inv...

Authors: Jie Zhang, Mingjuan Li, Mingyue Wang, Hang Xu, Zhuoxiang Wang, Yue Li, Baoyue Ding and Jianqing Gao

ROS-responsive liposomes with NIR light-triggered doxorubicin release for combinatorial therapy of breast cancer

Reactive oxygen species (ROS)-responsive drug delivery systems (DDSs) are potential tools to minimize the side effects and substantially enhance the therapeutic efficacy of chemotherapy. However, it is challen...

Authors: Hanxi Yi, Wangxing Lu, Fan Liu, Guoqing Zhang, Feifan Xie, Wenjie Liu, Lei Wang, Wenhu Zhou and Zeneng Cheng

Expression and mechanism of exosome-mediated A FOXM1 related long noncoding RNA in gastric cancer

Forkhead box protein M1 (FOXM1) is an oncogene regulating tumor growth and metastasis. Exosome was suggested to mediate cell communication by delivering active molecules in cancers. However, the existence of F...

Authors: Yan Zhang, Lin Chen, Xuanting Ye, Zhixiong Wu, Zeyu Zhang, Biaofeng Sun, Hong Fu, Chuangang Fu, Xiaofei Liang and Hong Jiang

Recent advances in near-infrared II imaging technology for biological detection

Molecular imaging technology enables us to observe the physiological or pathological processes in living tissue at the molecular level to accurately diagnose diseases at an early stage. Optical imaging can be ...

Authors: Nan-nan Zhang, Chen-ying Lu, Min-jiang Chen, Xiao-ling Xu, Gao-feng Shu, Yong-zhong Du and Jian-song Ji

Electrospun fibrous sponge via short fiber for mimicking 3D ECM

Most of the natural extracellular matrix (ECM) is a three-dimensional (3D) network structure of micro/nanofibers for cell adhesion and growth of 3D. Electrospun fibers distinctive mimicked 2D ECM, however, it ...

Authors: Yan Li, Juan Wang, Dejian Qian, Liang Chen, Xiumei Mo, Lei Wang, Yan Wang and Wenguo Cui

Sustained delivery of MMP-9 siRNA via thermosensitive hydrogel accelerates diabetic wound healing

Excessive expression of matrix metalloproteinase 9 (MMP-9) impedes healing of diabetic chronic wounds, thus wound dressing that could effectively inhibit the expression of MMP-9 offers significant clinical tra...

Authors: Biyun Lan, Liming Zhang, Liqun Yang, Junfeng Wu, Na Li, Chenglin Pan, Xiaoyi Wang, Lexiang Zeng, Li Yan, Chuan Yang and Meng Ren

The unpredictable carbon nanotube biocorona and a functionalization method to prevent protein biofouling

The intrinsic physicochemical properties of carbon nanotubes (CNTs) make them unique tools in nanotechnology. Their elemental composition, resilience, thermal properties, and surface reactivity make CNTs also ...

Authors: Lorena García-Hevia, Mahsa Saramiforoshani, Jorge Monge, Nerea Iturrioz-Rodríguez, Esperanza Padín-González, Fernando González, Lorena González-Legarreta, Jesús González and Mónica L. Fanarraga

Enhancement of doxorubicin anti-cancer activity by vascular targeting using IsoDGR/cytokine-coated nanogold

Gold nanospheres tagged with peptides containing isoDGR (isoAsp-Gly-Arg), an αvβ3 integrin binding motif, represent efficient carriers for delivering pro-inflammatory cytokines to the tumor vasculature. We prepar...

Authors: Angelo Corti, Angelina Sacchi, Anna Maria Gasparri, Matteo Monieri, Giulia Anderluzzi, Barbara Colombo, Alessandro Gori, Anna Mondino and Flavio Curnis

Exploiting the anticancer effects of a nitrogen bisphosphonate nanomedicine for glioblastoma multiforme

Glioblastoma multiforme (GBM) is an incurable aggressive brain cancer in which current treatment strategies have demonstrated limited survival benefit. In recent years, nitrogen-containing bisphosphonates (N-B...

Authors: Lynn N Jena, Lindsey A Bennie, Emma M McErlean, Sreekanth Pentlavalli, Kim Glass, James F Burrows, Vicky L Kett, Niamh E Buckley, Jonathan A Coulter, Nicholas J Dunne and Helen O McCarthy

Self-synergistic effect of Prussian blue nanoparticles for cancer therapy: driving photothermal therapy and reducing hyperthermia-induced side effects

Photothermal therapy (PTT), involving application of localized hyperthermia to kill cancer cells, has attracted wide attention in cancer therapy. The production of reactive oxygen species (ROS) during PTT may ...

Authors: Xue Xie, Wei Gao, Junnian Hao, Jianrong Wu, Xiaojun Cai and Yuanyi Zheng

Construction of nanomaterials as contrast agents or probes for glioma imaging

Malignant glioma remains incurable largely due to the aggressive and infiltrative nature, as well as the existence of blood–brain-barrier (BBB). Precise diagnosis of glioma, which aims to accurately delineate ...

Authors: Wei Zhao, Xiangrong Yu, Shaojun Peng, Yu Luo, Jingchao Li and Ligong Lu

Co-administration of combretastatin A4 nanoparticles and anti-PD-L1 for synergistic therapy of hepatocellular carcinoma

According to data estimated by the WHO, primary liver cancer is currently the fourth most common malignant tumor and the second leading cause of death around the world. Hepatocellular carcinoma (HCC) is one of...

Authors: Bonan Zhao, Zhipeng Dong, Weixing Liu, Fangning Lou, Qiyan Wang, Hao Hong and Yue Wang

A heparin–rosuvastatin-loaded P(LLA-CL) nanofiber-covered stent inhibits inflammatory smooth-muscle cell viability to reduce in-stent stenosis and thrombosis

An endovascular covered-stent has unique advantages in treating complex intracranial aneurysms; however, in-stent stenosis and late thrombosis have become the main factors affecting the efficacy of covered-ste...

Authors: Yingjun Liu, Peixi Liu, Yaying Song, Sichen Li, Yuan Shi, Kai Quan, Guo Yu, Peiliang Li, Qingzhu An and Wei Zhu

Nanomedicine-based technologies and novel biomarkers for the diagnosis and treatment of Alzheimer’s disease: from current to future challenges

Increasing life expectancy has led to an aging population, which has consequently increased the prevalence of dementia. Alzheimer's disease (AD), the most common form of dementia worldwide, is estimated to mak...

Authors: Amanda Cano, Patric Turowski, Miren Ettcheto, Jason Thomas Duskey, Giovanni Tosi, Elena Sánchez-López, Maria Luisa García, Antonio Camins, Eliana B. Souto, Agustín Ruiz, Marta Marquié and Mercè Boada

Phagocytosis of polymeric nanoparticles aided activation of macrophages to increase atherosclerotic plaques in ApoE^−/− mice

The unique physiochemical properties of nanomaterials have been widely used in drug delivery systems and diagnostic contrast agents. The safety issues of biomaterials with exceptional biocompatibility and hemo...

Authors: Tieying Yin, Yanhong Li, Yuzhen Ren, Atik Rohmana Maftuhatul Fuad, Fangfang Hu, Ruolin Du, Yang Wang, Guixue Wang and Yazhou Wang

Bacterial extracellular electron transfer: a powerful route to the green biosynthesis of inorganic nanomaterials for multifunctional applications

Synthesis of inorganic nanomaterials such as metal nanoparticles (MNPs) using various biological entities as smart nanofactories has emerged as one of the foremost scientific endeavors in recent years. The bio...

Authors: Long Zou, Fei Zhu, Zhong-er Long and Yunhong Huang

Correction to: A DM1-doped porous gold nanoshell system for NIR accelerated redox-responsive release and triple modal imaging guided photothermal synergistic chemotherapy

An amendment to this paper has been published and can be accessed via the original article.

Authors: Pengcheng Xu, Ru Wang, Wenqian Yang, Yanyan Liu, Dongsheng He, Zixuan Ye, Daquan Chen, Yuan Ding, Jiasheng Tu and Yan Shen

Correction to: Advances in the development paradigm of biosample‐based biosensors for early ultrasensitive detection of alzheimer’s disease

An amendment to this paper has been published and can be accessed via the original article.

Authors: Hem Prakash Karki, Yeongseok Jang, Jinmu Jung and Jonghyun Oh

Transient cell stiffening triggered by magnetic nanoparticle exposure

The interactions between nanoparticles and the biological environment have long been studied, with toxicological assays being the most common experimental route. In parallel, recent growing evidence has brough...

Authors: Jose E. Perez, Florian Fage, David Pereira, Ali Abou-Hassan, Sophie Asnacios, Atef Asnacios and Claire Wilhelm

Immunoengineered magnetic-quantum dot nanobead system for the isolation and detection of circulating tumor cells

Highly efficient capture and detection of circulating tumor cells (CTCs) remain elusive mainly because of their extremely low concentration in patients’ peripheral blood.

Authors: Pengfei Zhang, Mohamed S. Draz, Anwen Xiong, Wannian Yan, Huanxing Han and Wansheng Chen

A dual-targeting ruthenium nanodrug that inhibits primary tumor growth and lung metastasis via the PARP/ATM pathway

Many studies have found that ruthenium complexes possess unique biochemical characteristics and inhibit tumor growth or metastasis.

Authors: Yu Lu, Di Zhu, Lin Gui, Yuanming Li, Wenjing Wang, Jiawang Liu and Yuji Wang

Small-volume detection: platform developments for clinically-relevant applications

Biochemical analysis of human body fluids is a frequent and fruitful strategy for disease diagnosis. Point-of-care (POC) diagnostics offers the tantalizing possibility of providing rapid diagnostic results in ...

Authors: Wei-Hsuan Sung, Yu-Ting Tsao, Ching-Ju Shen, Chia-Ying Tsai and Chao-Min Cheng

Persistent luminescence nanoparticles for cancer theranostics application

Persistent luminescence nanoparticles (PLNPs) are unique optical materials that emit afterglow luminescence after ceasing excitation. They exhibit unexpected advantages for in vivo optical imaging of tumors, s...

Authors: Nian Liu, Xiao Chen, Xia Sun, Xiaolian Sun and Junpeng Shi

Autophagy blockade synergistically enhances nanosonosensitizer-enabled sonodynamic cancer nanotherapeutics

Ultrasound-triggered sonodynamic therapy (SDT) represents an emerging therapeutic modality for cancer treatment based on its specific feature of noninvasiveness, high tissue-penetrating depth and desirable the...

Authors: Liqiang Zhou, Minfeng Huo, Xiaoqin Qian, Li Ding, Luodan Yu, Wei Feng, Xinwu Cui and Yu Chen

Facile fabrication of multi-pocket nanoparticles with stepwise size transition for promoting deep penetration and tumor targeting

Nanocarriers-derived antitumor therapeutics are often associated with issues of limited tumor penetration and dissatisfactory antitumor efficacies. Some multistage delivery systems have been constructed to add...

Authors: Xingyu Hou, Dan Zhong, Yunkun Li, Hongli Mao, Jun Yang, Hu Zhang, Kui Luo, Qiyong Gong and Zhongwei Gu

Nanoparticle-mediated synergistic chemoimmunotherapy for tailoring cancer therapy: recent advances and perspectives

Nowadays, a potent challenge in cancer treatment is considered the lack of efficacious strategy, which has not been able to significantly reduce mortality. Chemoimmunotherapy (CIT) as a promising approach in b...

Authors: Rafieh Bagherifar, Seyed Hossein Kiaie, Zahra Hatami, Armin Ahmadi, Abdolvahid Sadeghnejad, Behzad Baradaran, Reza Jafari and Yousef Javadzadeh

Glycol chitosan-based tacrolimus-loaded nanomicelle therapy ameliorates lupus nephritis

Recently, we developed hydrophobically modified glycol chitosan (HGC) nanomicelles loaded with tacrolimus (TAC) (HGC-TAC) for the targeted renal delivery of TAC. Herein, we determined whether the administratio...

Authors: Chang Seong Kim, Ansuja Pulickal Mathew, Arathy Vasukutty, Saji Uthaman, Soo Yeon Joo, Eun Hui Bae, Seong Kwon Ma, In-Kyu Park and Soo Wan Kim

Nanomaterials and hepatic disease: toxicokinetics, disease types, intrinsic mechanisms, liver susceptibility, and influencing factors

The widespread use of nanomaterials (NMs) has raised concerns that exposure to them may introduce potential risks to the human body and environment. The liver is the main target organ for NMs. Hepatotoxic effe...

Authors: Ting Sun, Yiyuan Kang, Jia Liu, Yanli Zhang, Lingling Ou, Xiangning Liu, Renfa Lai and Longquan Shao

Antioxidant and C5a-blocking strategy for hepatic ischemia–reperfusion injury repair

Nonspecific liver uptake of nanomaterials after intravenous injection has hindered nanomedicine for clinical translation. However, nanomaterials’ propensity for liver distribution might enable their use in hep...

Authors: Xiaobing Zhang, Jiajia Hu, Kaelyn V. Becker, Jonathan W. Engle, Dalong Ni, Weibo Cai, Dong Wu and Shuping Qu

Nanotechnology based solutions for anti-leishmanial impediments: a detailed insight

As a neglected tropical disease, Leishmaniasis is significantly instigating morbidity and mortality across the globe. Its clinical spectrum varies from ulcerative cutaneous lesions to systemic immersion causin...

Authors: Humzah Jamshaid, Fakhar ud Din and Gul Majid Khan

Green Phellodendri Chinensis Cortex-based carbon dots for ameliorating imiquimod-induced psoriasis-like inflammation in mice

Carbon dots (CDs) with multifaceted advantages have provided hope for development brand-new nanodrug for treating thorny diseases. This study developed a green and simple calcination method to prepare novel CD...

Authors: Meiling Zhang, Jinjun Cheng, Jie Hu, Juan Luo, Yue Zhang, Fang Lu, Hui Kong, Huihua Qu and Yan Zhao

Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity

The ubiquitous nature of bacterial biofilms combined with the enhanced resistance towards antimicrobials has led to the development of an increasing number of strategies for biofilm eradication. Such strategie...

Authors: Caio H. N. Barros, Dishon W. Hiebner, Stephanie Fulaz, Stefania Vitale, Laura Quinn and Eoin Casey

Mutual influence of selenium nanoparticles and FGF2-STAB^® on biocompatible properties of collagen/chitosan 3D scaffolds: in vitro and ex ovo evaluation

In a biological system, nanoparticles (NPs) may interact with biomolecules. Specifically, the adsorption of proteins on the nanoparticle surface may influence both the nanoparticles' and proteins' overall bio-...

Authors: Johana Muchová, Vanessa Hearnden, Lenka Michlovská, Lucie Vištejnová, Anna Zavaďáková, Kristýna Šmerková, Silvia Kočiová, Vojtěch Adam, Pavel Kopel and Lucy Vojtová

Dual activity of PD-L1 targeted Doxorubicin immunoliposomes promoted an enhanced efficacy of the antitumor immune response in melanoma murine model

The immunomodulation of the antitumor response driven by immunocheckpoint inhibitors (ICIs) such as PD-L1 (Programmed Death Ligand-1) monoclonal antibody (α-PD-L1) have shown relevant clinical outcomes in a su...

Authors: María Merino, Teresa Lozano, Noelia Casares, Hugo Lana, Iñaki F. Troconiz, Timo L. M. ten Hagen, Grazyna Kochan, Pedro Berraondo, Sara Zalba and María J. Garrido

Selenium nanoparticles produce a beneficial effect in psoriasis by reducing epidermal hyperproliferation and inflammation

Psoriasis is a chronic autoimmune skin disease characterized by hyperproliferation of keratinocytes. Wide treatment options used to treat psoriasis is associated with various adverse effects. To overcome this ...

Authors: Vinod Gangadevi, Sowjanya Thatikonda, Venkatesh Pooladanda, Geetanjali Devabattula and Chandraiah Godugu

Central composite design for the development of carvedilol-loaded transdermal ethosomal hydrogel for extended and enhanced anti-hypertensive effect

Carvedilol, the anti-hypertensive drug, has poor bioavailability when administered orally. Ethosomes-mediated transdermal delivery is considered a potential route of administration to increase the bioavailabil...

Authors: Padmanabha Rao Amarachinta, Garima Sharma, Noufel Samed, Ananda Kumar Chettupalli, Madhusudhan Alle and Jin-Chul Kim

On-demand pH-sensitive surface charge-switchable polymeric micelles for targeting Pseudomonas aeruginosa biofilms development

Bacterial biofilm is the complicated clinical issues, which usually results in bacterial resistance and reduce the therapeutic efficacy of antibiotics. Although micelles have been drawn attention in treatment ...

Authors: Xiangjun Chen, Rong Guo, Changrong Wang, Keke Li, Xinyu Jiang, Huayu He and Wei Hong

Ruthenium-loaded mesoporous silica as tumor microenvironment-response nano-fenton reactors for precise cancer therapy

Nano-Fenton reactors as novel strategy to selectively convert hydrogen peroxide (H₂O₂) into active hydroxyl radicals in tumor microenvironment for cancer therapy had attracted much attention. However, side effect...

Authors: Dongdong Sun, Zekun Wang, Pu Zhang, Chenyang Yin, Jingyuan Wang, Yu Sun, Ying Chen, Weiyun Wang, Baoliang Sun and Cundong Fan

Nanotechnology: new opportunities for the development of patch‐clamps

The patch-clamp technique is one of the best approaches to investigate neural excitability. Impressive improvements towards the automation of the patch-clamp technique have been made, but obvious limitations a...

Authors: Jia Gao, Chunyang Liao, Sijin Liu, Tian Xia and Guibin Jiang

Biomedical applications of 2D monoelemental materials formed by group VA and VIA: a concise review

The development of two-dimensional (2D) monoelemental nanomaterials (Xenes) for biomedical applications has generated intensive interest over these years. In this paper, the biomedical applications using Xene-...

Authors: Ping Gao, Yufen Xiao, YuliangWang, Leijiao Li, Wenliang Li and Wei Tao

Bi-functionalized aminoguanidine-PEGylated periodic mesoporous organosilica nanoparticles: a promising nanocarrier for delivery of Cas9-sgRNA ribonucleoproteine

There is a great interest in the efficient intracellular delivery of Cas9-sgRNA ribonucleoprotein complex (RNP) and its possible applications for in vivo CRISPR-based gene editing. In this study, a nanoporous ...

Authors: Pardis Rahimi Salekdeh, Leila Ma’mani, Javad Tavakkoly-Bazzaz, Hossein Mousavi, Mohammad Hossein Modarressi and Ghasem Hosseini Salekdeh

Nanoscale microenvironment engineering for expanding human hair follicle stem cell and revealing their plasticity

Periodically regenerated hair follicles provide an excellent research model for studying tissue regeneration and stem cell homeostasis. Periodic activation and differentiation of hair follicle stem cells (HFSC...

Authors: Peng Chen, Feifei Zhang, Zhexiang Fan, Tianding Shen, Bingcheng Liu, Ruosi Chen, Qian Qu, Jin Wang, Yong Miao and Zhiqi Hu

Engineering of bioactive metal sulfide nanomaterials for cancer therapy

Metal sulfide nanomaterials (MeSNs) are a novel class of metal-containing nanomaterials composed of metal ions and sulfur compounds. During the past decade, scientists found that the MeSNs engineered by specif...

Authors: Weidong Fei, Meng Zhang, Xiaoyu Fan, Yiqing Ye, Mengdan Zhao, Caihong Zheng, Yangyang Li and Xiaoling Zheng

Ultrasound targeted microbubble destruction combined with Fe-MOF based bio-/enzyme-mimics nanoparticles for treating of cancer

Authors: Xi Xiang, Houqing Pang, Tian Ma, Fangxue Du, Ling Li, Jianbo Huang, Lang Ma and Li Qiu

Correction to: Graphene-modified CePO₄ nanorods effectively treat breast cancer-induced bone metastases and regulate macrophage polarization to improve osteo-inductive ability

An amendment to this paper has been published and can be accessed via the original article.

Authors: Yu-Wei Ge, Xiao-Liang Liu, De-gang Yu, Zhen-An Zhu, Qin-Fei Ke, Yuan-Qing Mao, Ya-Ping Guo and Jing-Wei Zhang

BiVO₄/Fe₃O₄@polydopamine superparticles for tumor multimodal imaging and synergistic therapy

Despite tremendous progress has been achieved in tumor theranostic over the past decade, accurate identification and complete eradication of tumor cells remain a great challenge owing to the limitation of sing...

Authors: Ze Wang, Guan Wang, Tingting Kang, Shuwei Liu, Lu Wang, Haoyang Zou, Yu Chong and Yi Liu

Targeting triple‐negative breast cancer with an aptamer‐functionalized nanoformulation: a synergistic treatment that combines photodynamic and bioreductive therapies

Areas of hypoxia are often found in triple-negative breast cancer (TNBC), it is thus more difficult to treat than other types of breast cancer, and may require combination therapies. A new strategy that combin...

Authors: Yi-Te Chou, Chih-Yu Lin, Jyun-Wei Wen, Ling-Chun Hung, Ying-Feng Chang, Chia-Min Yang, Li-chen Wu and Ja-an Annie Ho

Correction to: M2 Macrophagy-derived exosomal miRNA-5106 induces bone mesenchymal stem cells towards osteoblastic fate by targeting salt-inducible kinase 2 and 3

An amendment to this paper has been published and can be accessed via the original article.

Authors: Yuan Xiong, Lang Chen, Chenchen Yan, Wu Zhou, Tao Yu, Yun Sun, Faqi Cao, Hang Xue, Yiqiang Hu, Dong Chen, Bobin Mi and Guohui Liu

Hypoxia modulation by dual-drug nanoparticles for enhanced synergistic sonodynamic and starvation therapy

Sonodynamic therapy (SDT) is an emerging non-invasive therapeutic technique. SDT-based cancer therapy strategies are presently underway, and it may be perceived as a promising approach to improve the efficienc...

Authors: Jingxue Wang, Ju Huang, Weichen Zhou, Jiawen Zhao, Qi Peng, Liang Zhang, Zhigang Wang, Pan Li and Rui Li

Green synthesis of metal nanoparticles using microorganisms and their application in the agrifood sector

The agricultural sector is currently facing many global challenges, such as climate change, and environmental problems such as the release of pesticides and fertilizers, which will be exacerbated in the face o...

Authors: Howra Bahrulolum, Saghi Nooraei, Nahid Javanshir, Hossein Tarrahimofrad, Vasighe Sadat Mirbagheri, Andrew J. Easton and Gholamreza Ahmadian