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  1. The failure of orthopedic and dental implants is mainly caused by biomaterial-associated infections and poor osseointegration. Surface modification of biomedical materials plays a significant role in enhancing...

    Authors: Libin Lu, Jiaru Zhang, Kai Guan, Jin Zhou, Fusong Yuan and Yingchun Guan
    Citation: Journal of Nanobiotechnology 2022 20:365
  2. Magnetosomes (BMPs) are organelles of magnetotactic bacteria (MTB) that are responsible for mineralizing iron to form magnetite. In addition, BMP is an ideal biomaterial that is widely used in bio- and nano-te...

    Authors: Junjie Xu, Shijiao Ma, Wei Zhang, Lina Jia, Haolan Zheng, Pang Bo, Xue Bai, Hongyan Sun, Lei Qi, Tongwei Zhang, Chuanfang Chen, Feng Li, Fumihito Arai, Jiesheng Tian and Lin Feng
    Citation: Journal of Nanobiotechnology 2022 20:364
  3. With the success of recent non-viral gene delivery-based COVID-19 vaccines, nanovectors have gained some public acceptance and come to the forefront of advanced therapies. Unfortunately, the relatively low abi...

    Authors: Federica Ponti, Nina Bono, Luca Russo, Paolo Bigini, Diego Mantovani and Gabriele Candiani
    Citation: Journal of Nanobiotechnology 2022 20:363

    The Correction to this article has been published in Journal of Nanobiotechnology 2022 20:489

  4. Oral delivery of therapeutics is the preferred route of administration due to ease of administration which is associated with greater patient medication adherence. One major barrier to oral delivery and intest...

    Authors: Deepak A. Subramanian, Robert Langer and Giovanni Traverso
    Citation: Journal of Nanobiotechnology 2022 20:362
  5. Ocular drug delivery is one of the most challenging endeavors among the various available drug delivery systems. Despite having suitable drugs for the treatment of ophthalmic disease, we have not yet succeeded...

    Authors: Mehrdad Afarid, Shirin Mahmoodi and Roghayyeh Baghban
    Citation: Journal of Nanobiotechnology 2022 20:361
  6. Exosomes show potential for treating patients with spinal cord injury (SCI) in clinical practice, but the underlying repair mechanisms remain poorly understood, and biological scaffolds available for clinical ...

    Authors: Xiaolie He, Li Yang, Kun Dong, Feng Zhang, Yuchen Liu, Bei Ma, Youwei Chen, Jian Hai, Rongrong Zhu and Liming Cheng
    Citation: Journal of Nanobiotechnology 2022 20:360
  7. The conversion of tumor-promoting M2 macrophage phenotype to tumor-suppressing M1 macrophages is a promising therapeutic approach for cancer treatment. However, the tumor normally provides an abundance of M2 m...

    Authors: Yongmei Zhao, Yuanlin Zheng, Yan Zhu, Hongyun Li, Hongyan Zhu and Tianqing Liu
    Citation: Journal of Nanobiotechnology 2022 20:359
  8. Laccase-based biosensors are efficient for detecting phenolic compounds. However, the instability and high cost of laccases have hindered their practical utilization.

    Authors: Thao Nguyen Le, Xuan Ai Le, Tai Duc Tran, Kang Jin Lee and Moon Il Kim
    Citation: Journal of Nanobiotechnology 2022 20:358
  9. The exosomal miRNA (exo-miRNA) derived from tumor cells contains rich biological information that can effectively aid in the early diagnosis of disease. However, the extremely low abundance imposes stringent r...

    Authors: Xin Gao, Haiping Wu, Yujian Li, Lu Zhang, Mingxuan Song, Xuhuai Fu, Rui Chen, Shijia Ding, Jiawei Zeng, Jia Li and Ping Liu
    Citation: Journal of Nanobiotechnology 2022 20:357
  10. Due to their prevalence, dental caries ranks first among all diseases endangering human health. Therefore, the prevention of caries is of great significance, as caries have become a serious public health probl...

    Authors: Luting Weng, Lang Wu, Rongjuan Guo, Jiajia Ye, Wen Liang, Wei Wu, Liang Chen and Deqin Yang
    Citation: Journal of Nanobiotechnology 2022 20:356
  11. The CRISPR-Cas9 technology has changed the landscape of genome editing and has demonstrated extraordinary potential for treating otherwise incurable diseases. Engineering strategies to enable efficient intrace...

    Authors: Tianxu Fang, Xiaona Cao, Mysha Ibnat and Guojun Chen
    Citation: Journal of Nanobiotechnology 2022 20:354
  12. Human umbilical cord mesenchymal stem cells-derived small extracellular vesicles (hucMSC-sEVs) have been demonstrated as a therapeutic agent to prevent and treat cisplatin-induced acute kidney injury (AKI). Ho...

    Authors: Peipei Wu, Yuting Tang, Can Jin, Min Wang, Linli Li, Zhong Liu, Hui Shi, Zixuan Sun, Xiaomei Hou, Wenya Chen, Wenrong Xu and Hui Qian
    Citation: Journal of Nanobiotechnology 2022 20:353
  13. Fullerenol, a functional and water-soluble fullerene derivative, plays an important role in antioxidant, antitumor and antivirus, implying its enormous potential in biomedical applications. However, the in viv...

    Authors: Yingying Zha, Yan Jin, Xinxing Wang, Lin Chen, Xulai Zhang and Ming Wang
    Citation: Journal of Nanobiotechnology 2022 20:348
  14. Coronaviruses usually cause mild respiratory disease in humans but as seen recently, some human coronaviruses can cause more severe diseases, such as the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-C...

    Authors: Marta L. DeDiego, Yadileiny Portilla, Neus Daviu, Darío López-García, Laura Villamayor, Vladimir Mulens-Arias, Jesús G. Ovejero, Álvaro Gallo-Cordova, Sabino Veintemillas-Verdaguer, M. Puerto Morales and Domingo F. Barber
    Citation: Journal of Nanobiotechnology 2022 20:352
  15. The efficacy of immune checkpoint blockade (ICB), in the treatment of hepatocellular carcinoma (HCC), is limited due to low levels of tumor-infiltrating T lymphocytes and deficient checkpoint blockade in this ...

    Authors: Yuan-Fei Lu, Jia-Ping Zhou, Qiao-Mei Zhou, Xiao-Yan Yang, Xiao-Jie Wang, Jie-Ni Yu, Jin-Guo Zhang, Yong-Zhong Du and Ri-Sheng Yu
    Citation: Journal of Nanobiotechnology 2022 20:351
  16. Magnetic resonance imaging (MRI) has been widely using in clinical diagnosis, and contrast agents (CAs) can improve the sensitivity MRI. To overcome the problems of commercial Gd chelates-based T1 CAs, commercial...

    Authors: Xuanyi Lu, Huimin Zhou, Zhiyu Liang, Jie Feng, Yudie Lu, Lin Huang, Xiaozhong Qiu, Yikai Xu and Zheyu Shen
    Citation: Journal of Nanobiotechnology 2022 20:350
  17. Non-alcoholic fatty liver disease (NAFLD) is a usual chronic liver disease and lacks non-invasive biomarkers for the clinical diagnosis and prognosis. Extracellular vesicles (EVs), a group of heterogeneous sma...

    Authors: Qingfu Zhu, Hengrui Li, Zheng Ao, Hao Xu, Jiaxin luo, Connor Kaurich, Rui Yang, Pei-Wu Zhu, Sui-Dan Chen, Xiao-Dong Wang, Liang-Jie Tang, Gang Li, Ou-Yang Huang, Ming-Hua Zheng, Hui-Ping Li and Fei Liu
    Citation: Journal of Nanobiotechnology 2022 20:349
  18. The disease caused by plant pathogenic bacteria in the production, transportation, and storage of many crops has brought huge losses to agricultural production. N-acylhomoserine lactonases (AHLases) can quench qu...

    Authors: Yan Chen, Pengfu Liu, Jiequn Wu, Wanqing Yan, Saixue Xie, Xuanrong Sun, Bang-Ce Ye and Xiaohe Chu
    Citation: Journal of Nanobiotechnology 2022 20:347
  19. Endogenous hydrogen sulfide (H2S)-responsive theranostic agents have attracted extensive attention due to their specificity for colon cancer. However, the development of such agents with high enrichment in tumors...

    Authors: Yuying Cheng, Haiji Bo, Ruomeng Qin, Fulai Chen, Fengfeng Xue, Lu An, Gang Huang and Qiwei Tian
    Citation: Journal of Nanobiotechnology 2022 20:346
  20. Nanovaccines, a new generation of vaccines that use nanoparticles as carriers and/or adjuvants, have been widely used in the prevention and treatment of various diseases, including cancer. Nanovaccines have sp...

    Authors: Zhiyun Liao, Jing Huang, Pui-Chi Lo, Jonathan F. Lovell, Honglin Jin and Kunyu Yang
    Citation: Journal of Nanobiotechnology 2022 20:345
  21. Cancer remains a serious threat to human health owing to the lack of effective treatments. Photodynamic therapy (PDT) has emerged as a promising non-invasive cancer treatment that consists of three main elemen...

    Authors: Zijuan Meng, Huiying Xue, Tingting Wang, Biao Chen, Xiyuan Dong, Lili Yang, Jun Dai, Xiaoding Lou and Fan Xia
    Citation: Journal of Nanobiotechnology 2022 20:344
  22. Promoting diabetic wound healing is still a challenge, and angiogenesis is believed to be essential for diabetic wound healing. Vermiculite is a natural clay material that is very easy to obtain and exhibits e...

    Authors: Xingtai Huang, Qirui Wang, Runyi Mao, Zeying Wang, Steve G.F. Shen, Juan Mou and Jiewen Dai
    Citation: Journal of Nanobiotechnology 2022 20:343
  23. Delayed wound healing remains a challenge, and macrophages play an important role in the inflammatory process of wound healing. Morphological changes in macrophages can affect their phenotype, but little is kn...

    Authors: Jian Xie, Xiaowei Wu, Shang Zheng, Kaili Lin and Jiansheng Su
    Citation: Journal of Nanobiotechnology 2022 20:342
  24. Nowadays, nanoparticles (NPs) have evolved as multifunctional systems combining different custom anchorages which opens a wide range of applications in biomedical research. Thus, their pharmacological involvem...

    Authors: Ángela-Patricia Hernández, Ania Micaelo, Rafael Piñol, Marina L. García-Vaquero, José J. Aramayona, Julio J. Criado, Emilio Rodriguez, José Ignacio Sánchez-Gallego, Alicia Landeira-Viñuela, Pablo Juanes-Velasco, Paula Díez, Rafael Góngora, Ricardo Jara-Acevedo, Alberto Orfao, Javier Miana-Mena, María Jesús Muñoz…
    Citation: Journal of Nanobiotechnology 2022 20:341
  25. Practice of tumor-targeted suicide gene therapy is hampered by unsafe and low efficient delivery of plasmid DNA (pDNA). Using HIV-Tat-derived peptide (Tat) to non-covalently form Tat/pDNA complexes advances th...

    Authors: Linjia Su, Zhe Sun, Fangzheng Qi, Huishan Su, Luomeng Qian, Jing Li, Liang Zuo, Jinhai Huang, Zhilin Yu, Jinping Li, Zhinan Chen and Sihe Zhang
    Citation: Journal of Nanobiotechnology 2022 20:340
  26. Currently, systemic therapies for patients with advanced-stage hepatocellular carcinoma (HCC) rely mainly on systemic drugs. However, traditional systemic drugs have a high rate of serious adverse events, and ...

    Authors: Yongshun Zheng, Ran Jia, Jun Li, Xiaohe Tian and Yeben Qian
    Citation: Journal of Nanobiotechnology 2022 20:339
  27. Cationic non-viral vectors show great potential to introduce genetic material into cells, due to their ability to transport large amounts of genetic material and their high synthetic versatility. However, desi...

    Authors: Jana I. Solomun, Liam Martin, Prosper Mapfumo, Elisabeth Moek, Elias Amro, Friedrich Becker, Stefan Tuempel, Stephanie Hoeppener, K. Lenhard Rudolph and Anja Traeger
    Citation: Journal of Nanobiotechnology 2022 20:336
  28. Cytomegalovirus (CMV) pneumonia is a major cause of morbidity and mortality in immunodeficiency individuals, including transplant recipients and Acquired Immune Deficiency Syndrome patients. Antiviral drugs ga...

    Authors: Aiping Qin, Sheng Chen, Songpei Li, Qizhen Li, Xiaotao Huang, Luoxing Xia, Yinshan Lin, Ao Shen, Andy Peng Xiang and Lingmin Zhang
    Citation: Journal of Nanobiotechnology 2022 20:335
  29. The pathogenesis of vascular calcification in diabetic patients remains elusive. As an effective information transmitter, small extracellular vesicles (sEVs) carry abundant microRNAs (miRNAs) that regulate the...

    Authors: Bei Guo, Su-Kang Shan, Feng Xu, Xiao Lin, Fu-Xing-zi Li, Yi Wang, Qiu-Shuang Xu, Ming-Hui Zheng, Li-Min Lei, Chang-Chun Li, Zhi-Ang Zhou, Muhammad Hasnain Ehsan Ullah, Feng Wu, Xiao-Bo Liao and Ling-Qing Yuan
    Citation: Journal of Nanobiotechnology 2022 20:334
  30. Red blood cell (RBC) hitchhiking has great potential in enhancing drug therapy, by improving targeting and reducing rapid clearance of nanoparticles (NPs). However, to improve the potential for clinical transl...

    Authors: Vincent Lenders, Remei Escudero, Xanthippi Koutsoumpou, Laura Armengol Álvarez, Jef Rozenski, Stefaan J. Soenen, Zongmin Zhao, Samir Mitragotri, Pieter Baatsen, Karel Allegaert, Jaan Toelen and Bella B. Manshian
    Citation: Journal of Nanobiotechnology 2022 20:333
  31. The development of chemo/photothermal nanotherapeutic systems with excellent photothermal performance, stable drug loading, tumor targeting and strong membrane penetration still remains a challenge. To address...

    Authors: Shaochen Wang, Qiaoqiao Zhou, Shuling Yu, Shuang Zhao, Jiahua Shi and Jintao Yuan
    Citation: Journal of Nanobiotechnology 2022 20:332
  32. Food-borne carbon dots (CDs) are widely generated during food processing and are inevitably ingested by humans causing toxicity. However, the toxic effects of food-borne CDs on the blood glucose metabolism are...

    Authors: Boya Zhang, Lidong Yu, Ruijiao Zhu, Xiangjuan Wei, Xingpei Fan, Hailong Hu, Daqian Yang, Haining Du, Meimei Zhao, Li Li, Yuri Oh, Yujie Feng and Ning Gu
    Citation: Journal of Nanobiotechnology 2022 20:331
  33. Radiodynamic therapy (RDT) holds the potential to overcome the shallow tissue penetration issue associated with conventional photodynamic therapy (PDT). To this end, complex and sometimes toxic scintillator–ph...

    Authors: Fangchao Jiang, Chaebin Lee, Weizhong Zhang, Wen Jiang, Zhengwei Cao, Harrison Byron Chong, Wei Yang, Shuyue Zhan, Jianwen Li, Yong Teng, Zibo Li and Jin Xie
    Citation: Journal of Nanobiotechnology 2022 20:330
  34. Photodynamic therapy (PDT) has emerged as an attractive therapeutic approach which can elicit immunogenic cell death (ICD). However, current ICD inducers are still very limited as the representative ICD induce...

    Authors: Haiqin Song, Zhenghao Cai, Juyi Li, Haihua Xiao, Ruogu Qi and Minhua Zheng
    Citation: Journal of Nanobiotechnology 2022 20:329
  35. Combating bacterial infections is one of the most important applications of nanomedicine. In the past two decades, significant efforts have been committed to tune physicochemical properties of nanomaterials fo...

    Authors: Youkun Zheng, Min Wei, Haibin Wu, Fangyuan Li and Daishun Ling
    Citation: Journal of Nanobiotechnology 2022 20:328
  36. Osteoarthritis (OA) is common musculoskeletal disorders associated with overgeneration of free radicals, and it causes joint pain, inflammation, and cartilage degradation. Lignin as a natural antioxidant biopo...

    Authors: Ruiming Liang, Xingchen Yang, Pek Yin Michelle Yew, Sigit Sugiarto, Qiang Zhu, Jinmin Zhao, Xian Jun Loh, Li Zheng and Dan Kai
    Citation: Journal of Nanobiotechnology 2022 20:327
  37. The prevalence of end-stage kidney disease (ESKD) is rapidly increasing with the need for regenerative therapies. Adult stem cell derived kidney tubuloids have the potential to functionally mimic the adult kid...

    Authors: Rafael Soares Lindoso, Fjodor A. Yousef Yengej, Franziska Voellmy, Maarten Altelaar, Estela Mancheño Juncosa, Theano Tsikari, Carola M. E. Ammerlaan, Bas W. M. Van Balkom, Maarten B. Rookmaaker, Marianne C. Verhaar and Rosalinde Masereeuw
    Citation: Journal of Nanobiotechnology 2022 20:326
  38. Building a novel and efficient photothermal antibacterial nanoplatform is a promising strategy for precise bacterial elimination. Herein, a nanocomposite NiO NPs@AuNPs@Van (NAV) for selective MRSA removal was ...

    Authors: Ting Du, Jiangli Cao, Zehui Xiao, Jiaqi Liu, Lifei Wei, Chunqiao Li, Jingbo Jiao, Zhiyong Song, Jifeng Liu, Xinjun Du and Shuo Wang
    Citation: Journal of Nanobiotechnology 2022 20:325
  39. Chronic inflammatory pain significantly reduces the quality of life and lacks effective interventions. In recent years, human umbilical cord mesenchymal stem cells (huc-MSCs)-derived exosomes have been used to...

    Authors: Tong Hua, Mei Yang, Honghao Song, Erliang Kong, Mengqiu Deng, Yongchang Li, Jian Li, Zhixiao Liu, Hailong Fu, Yue Wang and Hongbin Yuan
    Citation: Journal of Nanobiotechnology 2022 20:324
  40. In hypoxic dendritic cells (DCs), a low level of Zn2+ can induce the activation of immunogenic DCs (igDCs), thereby triggering an active T-cell response to propel the immune progression of rheumatoid arthritis (R...

    Authors: Han Qiao, Jingtian Mei, Kai Yuan, Kai Zhang, Feng Zhou, Tingting Tang and Jie Zhao
    Citation: Journal of Nanobiotechnology 2022 20:323
  41. Alzheimer's disease (AD) is the most common neurodegenerative disorder without effective therapy and lack diagnosis strategy for preclinical AD patients. There is an urgent need for development of both early d...

    Authors: Yuting Ruan, Ying Xiong, Wenli Fang, Qun Yu, Yingren Mai, Zhiyu Cao, Kexi Wang, Ming Lei, Jiaxin Xu, Yan Liu, Xingcai Zhang, Wang Liao and Jun Liu
    Citation: Journal of Nanobiotechnology 2022 20:322
  42. Enterococcus faecalis (E. faecalis) biofilm-associated persistent endodontic infections (PEIs) are one of the most common tooth lesions, causing chronic periapical periodontitis, root resorption, and even tooth ...

    Authors: Shang Tang, Hui Zhang, Li Mei, Keke Dou, Yuying Jiang, Zhanyi Sun, Shuai Wang, Mohamed Sayed Hasanin, Jing Deng and Qihui Zhou
    Citation: Journal of Nanobiotechnology 2022 20:321
  43. Nanovaccines have shown the promising potential in controlling and eradicating the threat of infectious diseases worldwide. There has been a great need in developing a versatile strategy to conveniently constr...

    Authors: Sisi Chen, Liu Yang, Xia Ou, Jin-Yu Li, Cheng-Ting Zi, Hao Wang, Jiang-Miao Hu and Ye Liu
    Citation: Journal of Nanobiotechnology 2022 20:320
  44. Chemoresistance is often a cause of the failure of chemotherapy in cancer treatment. Sorcin (SRI) is a soluble resistance-related calcium-binding protein involved in chemoresistant processes and is overexpress...

    Authors: Chenglong Wang, Xiaolin Xu, Peipei Zhang, Shuhan Xiong, Jia Yuan, Xuzhu Gao, Wencai Guan, Fanchen Wang, Xin Li, Hongjing Dou and Guoxiong Xu
    Citation: Journal of Nanobiotechnology 2022 20:319
  45. Cerebral malaria (CM) is a life-threatening neurological complication caused by Plasmodium falciparum. About 627,000 patients died of malaria in 2020. Currently, artemisinin and its derivatives are the front-l...

    Authors: Ya Tian, Zhongyuan Zheng, Xi Wang, Shuzhi Liu, Liwei Gu, Jing Mu, Xiaojun Zheng, Yujie Li and Shuo Shen
    Citation: Journal of Nanobiotechnology 2022 20:318
  46. Exosomes are nano-sized vesicles secreted by various cells into the intra and extracellular space and hence is an integral part of biological fluids including milk. In the last few decades, many research group...

    Authors: Vengala Rao Yenuganti, Sumbul Afroz, Rafiq Ahmad Khan, Chandrima Bharadwaj, Deepti Kailash Nabariya, Nagaraj Nayak, Madhuri Subbiah, Kumaraswami Chintala, Sharmistha Banerjee, Pallu Reddanna and Nooruddin Khan
    Citation: Journal of Nanobiotechnology 2022 20:317

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