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  1. The agricultural sector is currently facing many global challenges, such as climate change, and environmental problems such as the release of pesticides and fertilizers, which will be exacerbated in the face o...

    Authors: Howra Bahrulolum, Saghi Nooraei, Nahid Javanshir, Hossein Tarrahimofrad, Vasighe Sadat Mirbagheri, Andrew J. Easton and Gholamreza Ahmadian

    Citation: Journal of Nanobiotechnology 2021 19:86

    Content type: Review

    Published on:

  2. Graphene oxide (GO), a novel carbon-based nanomaterial, has promising applications in biomedicine. However, it induces potential cytotoxic effects on the gastrointestinal (GI) tract cells, and these effects ha...

    Authors: Siliang Liu, Angao Xu, Yanfei Gao, Yue Xie, Zhipeng Liu, Meiling Sun, Hua Mao and Xinying Wang

    Citation: Journal of Nanobiotechnology 2021 19:85

    Content type: Research

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  3. The development of nano delivery systems is rapidly emerging area of nanotechnology applications where nanomaterials (NMs) are employed to deliver therapeutic agents to specific site in a controlled manner. To...

    Authors: Priyadarshani S. Sadalage, Reshma V. Patil, Darshana V. Havaldar, Shruti S. Gavade, Ana Cláudia Santos and Kiran D. Pawar

    Citation: Journal of Nanobiotechnology 2021 19:84

    Content type: Research

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  4. Chemokine therapy with C–C motif chemokine ligand 25 (CCL25) is currently under investigation as a promising approach to treat articular cartilage degeneration. We developed a delayed release mechanism based o...

    Authors: J. Spinnen, K. Fröhlich, N. Sinner, M. Stolk, J. Ringe, L. Shopperly, M. Sittinger, T. Dehne and M. Seifert

    Citation: Journal of Nanobiotechnology 2021 19:83

    Content type: Research

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  5. Ischemic heart disease (IHD) is the leading cause of morbidity and mortality worldwide, and imposes a serious economic load. Thus, it is crucial to perform a timely and accurate diagnosis and monitoring in the...

    Authors: Xiajing Chen, Yanan Zhang, Hui Zhang, Liang Zhang, Lingjuan Liu, Yang Cao, Haitao Ran and Jie Tian

    Citation: Journal of Nanobiotechnology 2021 19:82

    Content type: Research

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  6. Triple-negative breast cancer (TNBC) is a kind of aggressive breast cancer with a high rate of metastasis, poor overall survival time, and a low response to targeted therapies. To improve the therapeutic effic...

    Authors: Hanyi Fang, Yongkang Gai, Sheng Wang, Qingyao Liu, Xiao Zhang, Min Ye, Jianling Tan, Yu Long, Kuanyin Wang, Yongxue Zhang and Xiaoli Lan

    Citation: Journal of Nanobiotechnology 2021 19:81

    Content type: Research

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  7. The recently developed biomimetic strategy is one of the mostly effective strategies for improving the theranostic efficacy of diverse nanomedicines, because nanoparticles coated with cell membranes can disgui...

    Authors: Yipengchen Yin, Yongjing Li, Sheng Wang, Ziliang Dong, Chao Liang, Jiaxin Sun, Changchun Wang, Rong Chai, Weiwei Fei, Jianping Zhang, Ming Qi, Liangzhu Feng and Qin Zhang

    Citation: Journal of Nanobiotechnology 2021 19:80

    Content type: Research

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  8. Osteosarcoma (OS) is the most common primary malignant bone tumor occurring in children and young adults. Drug-resistant osteosarcoma often results in chemotherapy failure. Therefore, new treatments aimed at n...

    Authors: Wei-Nan Zeng, Qiu-Ping Yu, Duan Wang, Jun-Li Liu, Qing-Jun Yang, Zong-Ke Zhou and Yi-Ping Zeng

    Citation: Journal of Nanobiotechnology 2021 19:79

    Content type: Research

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  9. Micro/nano-textured hierarchical titanium topography is more bioactive and biomimetic than smooth, micro-textured or nano-textured titanium topographies. Bone marrow mesenchymal stem cells (BMSCs) and exosomes...

    Authors: Zhengchuan Zhang, Ruogu Xu, Yang Yang, Chaoan Liang, Xiaolin Yu, Yun Liu, Tianlu Wang, Yi Yu and Feilong Deng

    Citation: Journal of Nanobiotechnology 2021 19:78

    Content type: Research

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  10. Although many treatments for breast cancer are available, poor tumour targeting limits the effectiveness of most approaches. Consequently, it is difficult to achieve satisfactory results with monotherapies. Th...

    Authors: Pengcheng Xu, Ru Wang, Wenqian Yang, Yanyan Liu, Dongsheng He, Zixuan Ye, Daquan Chen, Yuan Ding, Jiasheng Tu and Yan Shen

    Citation: Journal of Nanobiotechnology 2021 19:77

    Content type: Research

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    The Correction to this article has been published in Journal of Nanobiotechnology 2021 19:119

  11. Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis. Magnetic resonance imaging (MRI) is one of the most effective imaging methods for the early diagnosis of HCC. However, the curren...

    Authors: Kai Fan, Chengying Lu, Gaofeng Shu, Xiu-Ling Lv, Enqi Qiao, Nannan Zhang, Minjiang Chen, Jingjing Song, Fazong Wu, Zhongwei Zhao, Xiaoling Xu, Min Xu, Chunmiao Chen, Weibin Yang, Jihong Sun, Yongzhong Du…

    Citation: Journal of Nanobiotechnology 2021 19:76

    Content type: Research

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  12. Cadmium (Cd) is amongst the most toxic heavy metals that severely affects crop growth, whereas application of nanoparticles (NPs) to negate the toxic effects of heavy metals could be an effective management ap...

    Authors: Yuzhan Li, Luxin Liang, Wu Li, Umair Ashraf, Lin Ma, Xiangru Tang, Shenggang Pan, Hua Tian and Zhaowen Mo

    Citation: Journal of Nanobiotechnology 2021 19:75

    Content type: Research

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  13. This research was to develop a special method for enriching Circulating tumor cells (CTCs) of Hepatocellular carcinoma (HCC) by Glypican-3 immunoliposomes (GPC3-IML), and to analyze the correlation between the...

    Authors: Bin Yi, Tian Wu, Nan Zhu, Yao Huang, Xiaoyu Yang, Lei Yuan, Yingjun Wu, Xiaofei Liang and Xiaoqing Jiang

    Citation: Journal of Nanobiotechnology 2021 19:74

    Content type: Research

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    The Correction to this article has been published in Journal of Nanobiotechnology 2021 19:176

  14. Blood prostate-specific antigen (PSA) levels are widely used as diagnostic biomarkers for prostate cancer. Lateral-flow immunoassay (LFIA)-based PSA detection can overcome the limitations associated with other...

    Authors: Hyung-Mo Kim, Jaehi Kim, Jaehyun An, Sungje Bock, Xuan-Hung Pham, Kim-Hung Huynh, Yoonsik Choi, Eunil Hahm, Hobeom Song, Jung-Won Kim, Won-Yeop Rho, Dae Hong Jeong, Ho-Young Lee, Sangchul Lee and Bong-Hyun Jun

    Citation: Journal of Nanobiotechnology 2021 19:73

    Content type: Research

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  15. This review highlights current developments, challenges, and future directions for the use of invasive and noninvasive biosample-based small biosensors for early diagnosis of Alzheimer’s disease (AD) with biom...

    Authors: Hem Prakash Karki, Yeongseok Jang, Jinmu Jung and Jonghyun Oh

    Citation: Journal of Nanobiotechnology 2021 19:72

    Content type: Review

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    The Correction to this article has been published in Journal of Nanobiotechnology 2021 19:118

  16. siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, ...

    Authors: Ezgi Oner, Mustafa Kotmakci, Anne-Marie Baird, Steven G. Gray, Bilge Debelec Butuner, Emir Bozkurt, Ayse Gulten Kantarci and Stephen P. Finn

    Citation: Journal of Nanobiotechnology 2021 19:71

    Content type: Research

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  17. Although there has been substantial progress in the research field of gene delivery, there are some challenges remaining, e.g. there are still cell types such as primary cells and suspension cells (immune cell...

    Authors: Friederike Richter, Prosper Mapfumo, Liam Martin, Jana I. Solomun, Franziska Hausig, Jochen J. Frietsch, Thomas Ernst, Stephanie Hoeppener, Johannes C. Brendel and Anja Traeger

    Citation: Journal of Nanobiotechnology 2021 19:70

    Content type: Research

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  18. Escherichia coli K1 (E. coli K1) caused neonatal meningitis remains a problem, which rises the urgent need for an effective vaccine. Previously, we rationally designed and produced the recombinant protein OmpAVa...

    Authors: Jin Zhang, Hongwu Sun, Chen Gao, Ying Wang, Xin Cheng, Yun Yang, Qiang Gou, Langhuang Lei, Yanping Chen, Xingyong Wang, Quanming Zou and Jiang Gu

    Citation: Journal of Nanobiotechnology 2021 19:69

    Content type: Research

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  19. It was shown that some nanomaterials may have anticancer properties, but lack of selectivity is one of challenges, let alone selective suppression of cancer growth by regulating the cellular microenvironment. ...

    Authors: Daomei Chen, Bin Li, Tao Lei, Di Na, Minfang Nie, Yepeng Yang, Congjia, Xie, Zijuan He and Jiaqiang Wang

    Citation: Journal of Nanobiotechnology 2021 19:68

    Content type: Research

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  20. Nanoparticles assembled from food-grade calcium carbonate have attracted attention because of their biocompatibility, digestibility, particle and surface features (such as size, surface area, and partial wetta...

    Authors: Xiaoming Guo, Xiaoying Li, Leung Chan, Wei Huang and Tianfeng Chen

    Citation: Journal of Nanobiotechnology 2021 19:67

    Content type: Research

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  21. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yang Mu, Cunyu Jia, Xu Zheng, Haipeng Zhu, Xin Zhang, Haoran Xu, Baoyuan Liu, Qin Zhao and En-Min Zhou

    Citation: Journal of Nanobiotechnology 2021 19:66

    Content type: Correction

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    The original article was published in Journal of Nanobiotechnology 2021 19:34

  22. Human cytomegalovirus (HCMV) is a worldwide infection, causing different troublesome in immunosupressed patients and very related to Human Immunodeficiency Virus 1 (HIV-1) infection, mainly in developing count...

    Authors: I. Relaño-Rodríguez, M. S. Espinar-Buitrago, V. Martín-Cañadilla, R. Gómez-Ramirez, J. L. Jiménez and M. A. Muñoz-Fernández

    Citation: Journal of Nanobiotechnology 2021 19:65

    Content type: Research

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  23. Owing to high genetic diversities of tumor cells and low response rate of standard chemotherapy, patients with triple negative breast cancer (TNBC) have short progression-free survivals and poor outcomes, whic...

    Authors: Qunjiao Jiang, Li Liu, Qiuying Li, Yi Cao, Dong Chen, Qishi Du, Xiaobo Yang, Dongping Huang, Renjun Pei, Xing Chen and Gang Huang

    Citation: Journal of Nanobiotechnology 2021 19:64

    Content type: Research

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  24. Hyperthermia is one of the promising cancer treatment strategies enabled by local heating with the use of tumor-targeting magnetic nanoparticles (MNP) under a non-invasive magnetic field. However, one of the r...

    Authors: Shan Zhao, Nanjing Hao, John X. J. Zhang, P. Jack Hoopes, Fridon Shubitidze and Zi Chen

    Citation: Journal of Nanobiotechnology 2021 19:63

    Content type: Research

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  25. Extensive application of nanomaterials has dramatically increased the risk of silica nanoparticle (SiNP, SiO2) exposure, yet their biological effect on reproduction has not been fully elucidated. By tracking the ...

    Authors: Shuyin Duan, Meihua Zhang, Junxia Li, Jiaqi Tian, Haoyu Yin, Xietong Wang and Lin Zhang

    Citation: Journal of Nanobiotechnology 2021 19:62

    Content type: Research

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  26. Exosome transplantation is a promising cell-free therapeutic approach for the treatment of ischemic heart disease. The purpose of this study was to explore whether exosomes derived from Macrophage migration in...

    Authors: Wenwu Zhu, Ling Sun, Pengcheng Zhao, Yaowu Liu, Jian Zhang, Yuelin Zhang, Yimei Hong, Yeqian Zhu, Yao Lu, Wei Zhao, Xinguang Chen and Fengxiang Zhang

    Citation: Journal of Nanobiotechnology 2021 19:61

    Content type: Research

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  27. Approximately 80% of brain tumours are gliomas. Despite treatment, patient mortality remains high due to local metastasis and relapse. It has been shown that transferrin-functionalised porous silicon nanoparti...

    Authors: Youssef Abdalla, Meihua Luo, Ermei Mäkilä, Bryan W. Day, Nicolas H. Voelcker and Wing Yin Tong

    Citation: Journal of Nanobiotechnology 2021 19:60

    Content type: Research

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  28. Virus-like particles (VLPs) are virus-derived structures made up of one or more different molecules with the ability to self-assemble, mimicking the form and size of a virus particle but lacking the genetic ma...

    Authors: Saghi Nooraei, Howra Bahrulolum, Zakieh Sadat Hoseini, Camellia Katalani, Abbas Hajizade, Andrew J. Easton and Gholamreza Ahmadian

    Citation: Journal of Nanobiotechnology 2021 19:59

    Content type: Review

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  29. The combination of an immuno-metabolic adjuvant and immune checkpoint inhibitors holds great promise for effective suppression of tumor growth and invasion. In this study, a pH-responsive co-delivery platform ...

    Authors: Chunai Gong, Xiaoyan Yu, Wei Zhang, Lu Han, Rong Wang, Yujie Wang, Shen Gao and Yongfang Yuan

    Citation: Journal of Nanobiotechnology 2021 19:58

    Content type: Research

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  30. Lung cancer is the most common type of tumour worldwide. Its relative lethality is considerably high. However, since the tumour tissues are located deep within the human body, traditional technologies, such as...

    Authors: Yanan Zhang, Abdur Rauf Khan, Xiaoye Yang, Yikang Shi, Xiaogang Zhao and Guangxi Zhai

    Citation: Journal of Nanobiotechnology 2021 19:57

    Content type: Research

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  31. Uncontrolled inflammation is a central problem for many respiratory diseases. The development of potent, targeted anti-inflammatory therapies to reduce lung inflammation and re-establish the homeostasis in the...

    Authors: Lu Wang, Yafei Rao, Xiali Liu, Liya Sun, Jiameng Gong, Huasheng Zhang, Lei Shen, Aihua Bao and Hong Yang

    Citation: Journal of Nanobiotechnology 2021 19:56

    Content type: Research

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  32. Triple negative breast cancer (TNBC) is one of the most biologically aggressive breast cancers and lacks effective treatment options, resulting in a poor prognosis. Therefore, studies aiming to explore new the...

    Authors: Chuanrong Chen, Ming Shen, Hongze Liao, Qianqian Guo, Hao Fu, Jian Yu and Yourong Duan

    Citation: Journal of Nanobiotechnology 2021 19:55

    Content type: Research

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  33. Gene and chemical therapy has become one of the rising stars in the field of molecular medicine during the last two decades. However, there are still numerous challenges in the development of efficient, target...

    Authors: Yuming Yang, Yu Han, Qiuyang Sun, Jin Cheng, Caixia Yue, Yanlei Liu, Jie Song, Weilin Jin, Xianting Ding, Jesús M. de la Fuente, Jian Ni, Xiaoqiang Wang and Daxiang Cui

    Citation: Journal of Nanobiotechnology 2021 19:54

    Content type: Research

    Published on:

  34. Biogenic nanoparticles possess a capping of biomolecules derived from the organism employed in the synthesis, which contributes to their stability and biological activity. These nanoparticles have been highlig...

    Authors: Mariana Guilger-Casagrande, Taís Germano-Costa, Natália Bilesky-José, Tatiane Pasquoto-Stigliani, Lucas Carvalho, Leonardo F. Fraceto and Renata de Lima

    Citation: Journal of Nanobiotechnology 2021 19:53

    Content type: Research

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  35. Sepsis is an emergency medical condition that can lead to death and it is defined as a life-threatening organ dysfunction caused by immune dysregulation in response to an infection. It is considered the main k...

    Authors: Davide Di Bella, João P. S. Ferreira, Renee de Nazare O. Silva, Cinthya Echem, Aline Milan, Eliana H. Akamine, Maria H. Carvalho and Stephen F. Rodrigues

    Citation: Journal of Nanobiotechnology 2021 19:52

    Content type: Research

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  36. Programmable nano-bio interfaces driven by tuneable vertically configured nanostructures have recently emerged as a powerful tool for cellular manipulations and interrogations. Such interfaces have strong pote...

    Authors: Roey Elnathan, Andrew W. Holle, Jennifer Young, Marina A. George, Omri Heifler, Andriy Goychuk, Erwin Frey, Ralf Kemkemer, Joachim P. Spatz, Alon Kosloff, Fernando Patolsky and Nicolas H. Voelcker

    Citation: Journal of Nanobiotechnology 2021 19:51

    Content type: Short Communication

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  37. Sialyl-Lewis X/L-selectin high affinity binding interactions between transmembrane O-glycosylated mucins proteins and the embryo have been implicated in implantation processes within the human reproductive sys...

    Authors: Lewis W. Francis, Seydou N. Yao, Lydia C. Powell, Sean Griffiths, Alexander Berquand, Thomas Piasecki, William Howe, Andrea S. Gazze, Mary C. Farach-Carson, Pamela Constantinou, Daniel Carson, Lavinia Margarit, Deya Gonzalez and R. Steven Conlan

    Citation: Journal of Nanobiotechnology 2021 19:50

    Content type: Research

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  38. Nanomaterials in plant protection promise many benefits over conventional pesticide products. Nano-enabled pesticides may alter the functionality or risk profile of active ingredients. Cationic nanochitin whis...

    Authors: Zhenya Li, Hezhong Wang, Shiheng An and Xinming Yin

    Citation: Journal of Nanobiotechnology 2021 19:49

    Content type: Research

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  39. Bacteremia-induced sepsis is a leading cause of mortality in intensive care units. To control a bacterial infection, an immune response is required, but this response might contribute to organ failure. Kidneys...

    Authors: Chia-Chih Liao, Huang-Ping Yu, Shih-Chun Yang, Ahmed Alalaiwe, You-Shan Dai, Fu-Chao Liu and Jia-You Fang

    Citation: Journal of Nanobiotechnology 2021 19:48

    Content type: Research

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  40. Protein tyrosine kinase 7 (PTK 7) is a membrane receptor, which can be found in various kinds of cancers. In view of this, detection of PTK 7 in the peripheral circulation would be an effective way for the ear...

    Authors: Yunsu Ma, Yuan Wang, Yongjie Liu, Lujia Shi and Dongzhi Yang

    Citation: Journal of Nanobiotechnology 2021 19:47

    Content type: Research

    Published on:

  41. Streptococcal infections are associated with life-threatening pneumonia and sepsis. The rise in antibiotic resistance calls for novel approaches to treat bacterial diseases. Anti-virulence strategies promote a...

    Authors: Hervé Besançon, Viktoriia Babiychuk, Yu Larpin, René Köffel, Dominik Schittny, Lara Brockhus, Lucy J. Hathaway, Parham Sendi, Annette Draeger and Eduard Babiychuk

    Citation: Journal of Nanobiotechnology 2021 19:46

    Content type: Research

    Published on:

  42. The cellular response to nanoparticles (NPs) for the mechanical clue and biochemical changes are unexplored. Here, we provide the comprehensive analysis of the Chinese Hamster Ovary (CHO-K1) cell line to study...

    Authors: Karmveer Yadav, Syed Azmal Ali, Ashok Kumar Mohanty, Eshwarmoorthy Muthusamy, Kesavan Subaharan and Gautam Kaul

    Citation: Journal of Nanobiotechnology 2021 19:45

    Content type: Research

    Published on:

  43. Gene silencing using siRNA can be a new potent strategy to treat many incurable diseases at the genetic level, including cancer and viral infections. Treatments using siRNA essentially requires an efficient an...

    Authors: Yeong Chae Ryu, Kyung Ah Kim, Byoung Choul Kim, Hui-Min David Wang and Byeong Hee Hwang

    Citation: Journal of Nanobiotechnology 2021 19:44

    Content type: Research

    Published on:

  44. A low pH environment is created due to the production of acids by oral biofilms that further leads to the dissolution of hydroxyapatite crystal in the tooth structure significantly altering the equilibrium. Al...

    Authors: Zohaib Akram, Sultan Aati, Hein Ngo and Amr Fawzy

    Citation: Journal of Nanobiotechnology 2021 19:43

    Content type: Research

    Published on:

  45. Although immunotherapy has revolutionized treatment strategies for some types of cancers, most patients failed to respond or obtain long-term benefit. Tumor-infiltrating CD8+ T lymphocytes are closely related to ...

    Authors: Haitao Zhao, Chao Wang, Yanling Yang, Yan Sun, Weijun Wei, Cheng Wang, Liangrong Wan, Cheng Zhu, Lianghua Li, Gang Huang and Jianjun Liu

    Citation: Journal of Nanobiotechnology 2021 19:42

    Content type: Research

    Published on:

  46. Owing to strong and tunable surface plasmon resonance (SPR) effect and good biocompatibility, gold nanoparticles have been suggested to be a versatile platform for a broad range of biomedical applications. In ...

    Authors: Beilei Gong, Yuanbing Shen, Huiyan Li, Xiaojun Li, Xia Huan, Jihong Zhou, Yuqing Chen, Jian Wu and Wei Li

    Citation: Journal of Nanobiotechnology 2021 19:41

    Content type: Research

    Published on:

  47. Cardiac arrest (CA) is a leading cause of death worldwide. Even after successful cardiopulmonary resuscitation (CPR), the majorities of survivals are companied with permanent myocardial and cerebral injury. Hy...

    Authors: Xiaotian Sun, Yiqing Wang, Shuyan Wen, Kai Huang, Jiechun Huang, Xianglin Chu, Fangrui Wang and Liewen Pang

    Citation: Journal of Nanobiotechnology 2021 19:40

    Content type: Research

    Published on:

  48. A limitation of current anticancer nanocarriers is the contradiction between multiple functions and favorable biocompatibility. Thus, we aimed to develop a compatible drug delivery system loaded with paclitaxe...

    Authors: Mingfang Wu, Chen Zhong, Qian Zhang, Lu Wang, Lingling Wang, Yanjie Liu, Xiaoxue Zhang and Xiuhua Zhao

    Citation: Journal of Nanobiotechnology 2021 19:39

    Content type: Research

    Published on:

  49. Increasing antibiotic resistance continues to focus on research into the discovery of novel antimicrobial agents. Due to its antimicrobial and wound healing-promoting activity, metal nanoparticles have attract...

    Authors: Reihaneh Haghniaz, Atiya Rabbani, Fereshteh Vajhadin, Taous Khan, Rozina Kousar, Abdul Rehman Khan, Hossein Montazerian, Javed Iqbal, Alberto Libanori, Han-Jun Kim and Fazli Wahid

    Citation: Journal of Nanobiotechnology 2021 19:38

    Content type: Research

    Published on:

  50. The aim to develop a highly stable near-infrared (NIR) photoinduced tumor therapy agent stems from its considerable potential for biological application. Due to its long wavelength, biological imaging exhibits...

    Authors: Yunjian Xu, Shiqi Wang, Zhenjiang Chen, Rui Hu, Shaoqiang Li, Yihua Zhao, Liwei Liu and Junle Qu

    Citation: Journal of Nanobiotechnology 2021 19:37

    Content type: Research

    Published on:

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