Deyo RA, Mirza SK. Clinical practice. Herniated lumbar intervertebral disk. N Engl J Med. 2016;374:1763–72.
Article
CAS
PubMed
Google Scholar
Richardson SM, Kalamegam G, Pushparaj PN, Matta C, Memic A, Khademhosseini A, Mobasheri R, Poletti FL, Hoyland JA, Mobasheri A. Mesenchymal stem cells in regenerative medicine: focus on articular cartilage and intervertebral disc regeneration. Methods. 2016;99:69–80.
Article
CAS
PubMed
Google Scholar
Henry N, Clouet J, Le Bideau J, Le Visage C, Guicheux J. Innovative strategies for intervertebral disc regenerative medicine: from cell therapies to multiscale delivery systems. Biotechnol Adv. 2018;36:281–94.
Article
CAS
PubMed
Google Scholar
Dowdell J, Erwin M, Choma T, Vaccaro A, Iatridis J, Cho SK. Intervertebral disk degeneration and repair. Neurosurgery. 2017;80:S46-s54.
Article
PubMed
PubMed Central
Google Scholar
Clouet J, Fusellier M, Camus A, Le Visage C, Guicheux J. Intervertebral disc regeneration: from cell therapy to the development of novel bioinspired endogenous repair strategies. Adv Drug Deliv Rev. 2019;146:306–24.
Article
CAS
PubMed
Google Scholar
Sakai D, Andersson GB. Stem cell therapy for intervertebral disc regeneration: obstacles and solutions. Nat Rev Rheumatol. 2015;11:243–56.
Article
PubMed
Google Scholar
Loebel C, Burdick JA. Engineering stem and stromal cell therapies for musculoskeletal tissue repair. Cell Stem Cell. 2018;22:325–39.
Article
CAS
PubMed
PubMed Central
Google Scholar
Phinney DG, Pittenger MF. Concise review: MSC-derived exosomes for cell-free therapy. Stem Cells. 2017;35:851–8.
Article
CAS
PubMed
Google Scholar
Alcaraz MJ, Compañ A, Guillén MI. Extracellular vesicles from mesenchymal stem cells as novel treatments for musculoskeletal diseases. Cells. 2019. https://doi.org/10.3389/fbioe.2020.624096/full.
Article
PubMed
PubMed Central
Google Scholar
Keshtkar S, Azarpira N, Ghahremani MH. Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine. Stem Cell Res Ther. 2018;9:63.
Article
CAS
PubMed
PubMed Central
Google Scholar
Brennan MA, Layrolle P, Mooney DJ. Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration. Adv Funct Mater. 2020;30:1909125.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liao Z, Luo R, Li G, Song Y, Zhan S, Zhao K, Hua W, Zhang Y, Wu X, Yang C. Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo. Theranostics. 2019;9:4084–100.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liao Z, Li S, Lu S, Liu H, Li G, Ma L, Luo R, Ke W, Wang B, Xiang Q, et al. Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration. Biomaterials. 2021;274: 120850.
Article
CAS
PubMed
Google Scholar
Liao Z, Liu H, Ma L, Lei J, Tong B, Li G, Ke W, Wang K, Feng X, Hua W, et al. Engineering extracellular vesicles restore the impaired cellular uptake and attenuate intervertebral disc degeneration. ACS Nano. 2021;15:14709–24.
Article
CAS
PubMed
Google Scholar
van Niel G, D’Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19:213–28.
Article
PubMed
CAS
Google Scholar
Tkach M, Théry C. Communication by extracellular vesicles: where we are and where we need to go. Cell. 2016;164:1226–32.
Article
CAS
PubMed
Google Scholar
Murphy C, Withrow J, Hunter M, Liu Y, Tang YL, Fulzele S, Hamrick MW. Emerging role of extracellular vesicles in musculoskeletal diseases. Mol Aspects Med. 2018;60:123–8.
Article
CAS
PubMed
Google Scholar
Mathieu M, Martin-Jaular L, Lavieu G, Théry C. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol. 2019;21:9–17.
Article
CAS
PubMed
Google Scholar
Huang A, Dong J, Li S, Wang C, Ding H, Li H, Su X, Ge X, Sun L, Bai C, et al. Exosomal transfer of vasorin expressed in hepatocellular carcinoma cells promotes migration of human umbilical vein endothelial cells. Int J Biol Sci. 2015;11:961–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ikeda Y, Imai Y, Kumagai H, Nosaka T, Morikawa Y, Hisaoka T, Manabe I, Maemura K, Nakaoka T, Imamura T, et al. Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. Proc Natl Acad Sci U S A. 2004;101:10732–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pintus G, Giordo R, Wang Y, Zhu W, Kim SH, Zhang L, Ni L, Zhang J, Telljohann R, McGraw KR, et al. Reduced vasorin enhances angiotensin II signaling within the aging arterial wall. Oncotarget. 2018;9:27117–32.
Article
PubMed
PubMed Central
Google Scholar
Bowles RD, Setton LA. Biomaterials for intervertebral disc regeneration and repair. Biomaterials. 2017;129:54–67.
Article
CAS
PubMed
PubMed Central
Google Scholar
Frapin L, Clouet J, Delplace V, Fusellier M, Guicheux J, Le Visage C. Lessons learned from intervertebral disc pathophysiology to guide rational design of sequential delivery systems for therapeutic biological factors. Adv Drug Deliv Rev. 2019;149–150:49–71.
Article
PubMed
CAS
Google Scholar
Pan Z, Sun H, Xie B, Xia D, Zhang X, Yu D, Li J, Xu Y, Wang Z, Wu Y, et al. Therapeutic effects of gefitinib-encapsulated thermosensitive injectable hydrogel in intervertebral disc degeneration. Biomaterials. 2018;160:56–68.
Article
CAS
PubMed
Google Scholar
Silva AKA, Perretta S, Perrod G, Pidial L, Lindner V, Carn F, Lemieux S, Alloyeau D, Boucenna I, Menasché P, et al. Thermoresponsive gel embedded with adipose stem-cell-derived extracellular vesicles promotes esophageal fistula healing in a thermo-actuated delivery strategy. ACS Nano. 2018;12:9800–14.
Article
CAS
PubMed
Google Scholar
Fiordalisi M, Silva AJ, Barbosa M, Goncalves R, Caldeira J. Decellularized scaffolds for intervertebral disc regeneration. Trends Biotechnol. 2020;38:947–51.
Article
CAS
PubMed
Google Scholar
Datta S, Rameshbabu AP, Bankoti K, Roy M, Gupta C, Jana S, Das AK, Sen R, Dhara S. Decellularized bone matrix/oleoyl chitosan derived supramolecular injectable hydrogel promotes efficient bone integration. Mater Sci Eng C Mater Biol Appl. 2021;119: 111604.
Article
CAS
PubMed
Google Scholar
Wu X, Liao Z, Wang K, Hua W, Liu X, Song Y, Zhang Y, Yang S, Yang C. Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc. Exp Mol Med. 2019;51:1–16.
PubMed
PubMed Central
Google Scholar
Liao Z, Wu X, Song Y, Luo R, Yin H, Zhan S, Li S, Wang K, Zhang Y, Yang C. Angiopoietin-like protein 8 expression and association with extracellular matrix metabolism and inflammation during intervertebral disc degeneration. J Cell Mol Med. 2019;23:5737–50.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bonnet AL, Chaussain C, Broutin I, Rochefort GY, Schrewe H, Gaucher C. From vascular smooth muscle cells to folliculogenesis: what about vasorin? Front Med (Lausanne). 2018;5:335.
Article
Google Scholar
Man J, Yu X, Huang H, Zhou W, Xiang C, Huang H, Miele L, Liu Z, Bebek G, Bao S, Yu JS. Hypoxic induction of vasorin regulates notch1 turnover to maintain glioma stem-like cells. Cell Stem Cell. 2018;22:104-118.e106.
Article
CAS
PubMed
Google Scholar
Dabral S, Tian X, Kojonazarov B, Savai R, Ghofrani HA, Weissmann N, Florio M, Sun J, Jonigk D, Maegel L, et al. Notch1 signalling regulates endothelial proliferation and apoptosis in pulmonary arterial hypertension. Eur Respir J. 2016;48:1137–49.
Article
CAS
PubMed
Google Scholar
Shu Y, Li W, Huang M, Quan YZ, Scheffer D, Tian C, Tao Y, Liu X, Hochedlinger K, Indzhykulian AA, et al. Renewed proliferation in adult mouse cochlea and regeneration of hair cells. Nat Commun. 2019;10:5530.
Article
CAS
PubMed
PubMed Central
Google Scholar
Almeida H, Amaral MH, Lobão P, Lobo JM. Pluronic® F-127 and Pluronic Lecithin Organogel (PLO): main features and their applications in topical and transdermal administration of drugs. J Pharm Pharm Sci. 2012;15:592–605.
Article
PubMed
Google Scholar
Savitri C, Ha SS, Liao E, Du P, Park K. Extracellular matrices derived from different cell sources and their effect on macrophage behavior and wound healing. J Mater Chem B. 2020;8:9744–55.
Article
CAS
PubMed
Google Scholar
Li YP, Liu W, Liu YH, Ren Y, Wang ZG, Zhao B, Huang S, Xu JZ, Li ZM. Highly improved aqueous lubrication of polymer surface by noncovalently bonding hyaluronic acid-based hydration layer for endotracheal intubation. Biomaterials. 2020;262: 120336.
Article
CAS
PubMed
Google Scholar
Li Z, Zhou F, Li Z, Lin S, Chen L, Liu L, Chen Y. Hydrogel cross-linked with dynamic covalent bonding and micellization for promoting burn wound healing. ACS Appl Mater Interfaces. 2018;10:25194–202.
Article
CAS
PubMed
Google Scholar
Dabrowska S, Andrzejewska A, Janowski M, Lukomska B. Immunomodulatory and regenerative effects of mesenchymal stem cells and extracellular vesicles: therapeutic outlook for inflammatory and degenerative diseases. Front Immunol. 2020;11: 591065.
Article
CAS
PubMed
Google Scholar
Nagelkerke A, Ojansivu M, van der Koog L, Whittaker TE, Cunnane EM, Silva AM, Dekker N, Stevens MM. Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities. Adv Drug Deliv Rev. 2021;175: 113775.
Article
CAS
PubMed
Google Scholar
Vadalà G, Ambrosio L, Russo F, Papalia R, Denaro V. Interaction between mesenchymal stem cells and intervertebral disc microenvironment: from cell therapy to tissue engineering. Stem Cells Int. 2019;2019:2376172.
Article
PubMed
PubMed Central
CAS
Google Scholar
Lyu FJ, Cheung KM, Zheng Z, Wang H, Sakai D, Leung VY. IVD progenitor cells: a new horizon for understanding disc homeostasis and repair. Nat Rev Rheumatol. 2019;15:102–12.
Article
PubMed
Google Scholar
Krut Z, Pelled G, Gazit D, Gazit Z. Stem cells and exosomes: new therapies for intervertebral disc degeneration. Cells. 2021. https://doi.org/10.3390/cells10092241.
Article
PubMed
PubMed Central
Google Scholar
Murali VP, Holmes CA. Biomaterial-based extracellular vesicle delivery for therapeutic applications. Acta Biomater. 2021;124:88–107.
Article
CAS
PubMed
Google Scholar
Khayambashi P, Iyer J, Pillai S, Upadhyay A, Zhang Y, Tran SD. Hydrogel encapsulation of mesenchymal stem cells and their derived exosomes for tissue engineering. Int J Mol Sci. 2021. https://doi.org/10.3390/ijms22020684.
Article
PubMed
PubMed Central
Google Scholar
Zhang Y, Cai Z, Shen Y, Lu Q, Gao W, Zhong X, Yao K, Yuan J, Liu H. Hydrogel-load exosomes derived from dendritic cells improve cardiac function via Treg cells and the polarization of macrophages following myocardial infarction. J Nanobiotechnology. 2021;19:271.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xing H, Zhang Z, Mao Q, Wang C, Zhou Y, Zhou X, Ying L, Xu H, Hu S, Zhang N. Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration. J Nanobiotechnology. 2021;19:264.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sorushanova A, Delgado LM, Wu Z, Shologu N, Kshirsagar A, Raghunath R, Mullen AM, Bayon Y, Pandit A, Raghunath M, Zeugolis DI. The collagen suprafamily: from biosynthesis to advanced biomaterial development. Adv Mater. 2019;31: e1801651.
Article
PubMed
CAS
Google Scholar
Xia C, Zeng Z, Fang B, Tao M, Gu C, Zheng L, Wang Y, Shi Y, Fang C, Mei S, et al. Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects. Free Radic Biol Med. 2019;143:1–15.
Article
CAS
PubMed
Google Scholar
Xiang H, Su W, Wu X, Chen W, Cong W, Yang S, Liu C, Qiu C, Yang SY, Wang Y, et al. Exosomes derived from human urine-derived stem cells inhibit intervertebral disc degeneration by ameliorating endoplasmic reticulum stress. Oxid Med Cell Longev. 2020;2020:6697577.
PubMed
PubMed Central
Google Scholar
Xie L, Chen Z, Liu M, Huang W, Zou F, Ma X, Tao J, Guo J, Xia X, Lyu F, et al. MSC-derived exosomes protect vertebral endplate chondrocytes against apoptosis and calcification via the miR-31-5p/ATF6 axis. Mol Ther Nucleic Acids. 2020;22:601–14.
Article
CAS
PubMed
PubMed Central
Google Scholar
O’Brien K, Breyne K, Ughetto S, Laurent LC, Breakefield XO. RNA delivery by extracellular vesicles in mammalian cells and its applications. Nat Rev Mol Cell Biol. 2020;21:585–606.
Article
CAS
PubMed
PubMed Central
Google Scholar
DiStefano TJ, Vaso K, Danias G, Chionuma HN, Weiser JR, Iatridis JC. Extracellular vesicles as an emerging treatment option for intervertebral disc degeneration: therapeutic potential, translational pathways, and regulatory considerations. Adv Healthc Mater. 2021. https://doi.org/10.1002/adhm.202100596.
Article
PubMed
Google Scholar
Balistreri CR, Madonna R, Melino G, Caruso C. The emerging role of Notch pathway in ageing: Focus on the related mechanisms in age-related diseases. Ageing Res Rev. 2016;29:50–65.
Article
CAS
PubMed
Google Scholar
Wopat S, Bagwell J, Sumigray KD, Dickson AL, Huitema LFA, Poss KD, Schulte-Merker S, Bagnat M. Spine patterning is guided by segmentation of the notochord sheath. Cell Rep. 2018;22:2026–38.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hiyama A, Skubutyte R, Markova D, Anderson DG, Yadla S, Sakai D, Mochida J, Albert TJ, Shapiro IM, Risbud MV. Hypoxia activates the notch signaling pathway in cells of the intervertebral disc: implications in degenerative disc disease. Arthritis Rheum. 2011;63:1355–64.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang H, Tian Y, Wang J, Phillips KLE, Binch ALA, Dunn S, Cross A, Chiverton N, Zheng Z, Shapiro IM, et al. Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration. J Biol Chem. 2013;288:16761–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zheng Y, Liu C, Ni L, Liu Z, Mirando AJ, Lin J, et al. Cell type-specific effects of Notch signaling activation on intervertebral discs: Implications for intervertebral disc degeneration. J Cell Physiol. 2018;233:5431–40.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang X, Jiao Y, Pan Y, Zhang L, Gong H, Qi Y, Wang M, Gong H, Shao M, Wang X, Jiang D. Fetal dermal mesenchymal stem cell-derived exosomes accelerate cutaneous wound healing by activating notch signaling. Stem Cells Int. 2019;2019:2402916.
PubMed
PubMed Central
Google Scholar
Song Y, Li S, Geng W, Luo R, Liu W, Tu J, Wang K, Kang L, Yin H, Wu X, et al. Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration. Redox Biol. 2018;19:339–53.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yan Z, Pan Y, Wang S, Cheng M, Kong H, Sun C, Hu K, Chen T, Dong Q, Chen J. Static compression induces ECM remodeling and integrin α2β1 expression and signaling in a rat tail caudal intervertebral disc degeneration model. Spine (Phila Pa 1976). 2017. https://doi.org/10.1097/BRS.0000000000001856.
Article
Google Scholar
Tong W, Lu Z, Qin L, Mauck RL, Smith HE, Smith LJ, Malhotra NR, Heyworth MF, Caldera F, Enomoto-Iwamoto M, Zhang Y. Cell therapy for the degenerating intervertebral disc. Transl Res. 2017;181:49–58.
Article
PubMed
Google Scholar